Names & Taxonomy

Uniprot ID:
H0Y8E6
Entry Name:
H0Y8E6_HUMAN
Status:
unreviewed
Protein Names:
DNA helicase (EC 3.6.4.12) (Fragment)
Gene Names:
MCM2
Gene Names Primary:
MCM2
Organism:
Homo sapiens (Human)

Structure

Length:
836
Sequence:
XSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKESSRNASLAEAGIGAIPSQLLAIEPSLRRSGVPIGEVGVSQRQEARSFSSANTHWFLEDLLGPSCRDTMIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMILQQF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Catalytic Activity:
ATP + H(2)O = ADP + phosphate.
Gene Ontology Go:
MCM complex
nucleus
ATP binding
DNA binding
DNA helicase activity
DNA replication initiation
Gene Ontology Biological Process:
DNA replication initiation
Gene Ontology Molecular Function:
ATP binding
DNA binding
DNA helicase activity
Gene Ontology Cellular Component:
MCM complex
nucleus
Keywords:
ATP-binding
Complete proteome
DNA-binding
Helicase
Hydrolase
Nucleotide-binding
Nucleus
Proteomics identification
Reference proteome

Publication

PubMed ID:
16641997 18669648 19608861 21269460 21406692