Names & Taxonomy
- Uniprot ID:
- A0A0A0MSC5
- Entry Name:
- A0A0A0MSC5_HUMAN
- Status:
- unreviewed
- Protein Names:
- Follicle-stimulating hormone receptor (Follitropin receptor)
- Gene Names:
- FSHR
- Gene Names Primary:
- FSHR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 695
- Sequence:
- MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTSGSTYILVPLSHLAQN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
- Gene Ontology Go:
- cell surface
endosome
integral component of membrane
plasma membrane
follicle-stimulating hormone receptor activity
peptide hormone binding
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
basement membrane organization
cellular water homeostasis
locomotory behavior
negative regulation of bone resorption
neuron projection development
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of intracellular estrogen receptor signaling pathway
primary ovarian follicle growth
regulation of acetylcholine metabolic process
regulation of chromosome organization
regulation of hormone metabolic process
regulation of MAPK cascade
regulation of osteoclast differentiation
regulation of platelet-derived growth factor receptor signaling pathway
regulation of systemic arterial blood pressure
Sertoli cell development
Sertoli cell proliferation
spermatogenesis, exchange of chromosomal proteins
transcytosis
uterus development - Gene Ontology Biological Process:
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
basement membrane organization
cellular water homeostasis
locomotory behavior
negative regulation of bone resorption
neuron projection development
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of intracellular estrogen receptor signaling pathway
primary ovarian follicle growth
regulation of acetylcholine metabolic process
regulation of chromosome organization
regulation of hormone metabolic process
regulation of MAPK cascade
regulation of osteoclast differentiation
regulation of platelet-derived growth factor receptor signaling pathway
regulation of systemic arterial blood pressure
Sertoli cell development
Sertoli cell proliferation
spermatogenesis, exchange of chromosomal proteins
transcytosis
uterus development - Gene Ontology Molecular Function:
- follicle-stimulating hormone receptor activity
peptide hormone binding - Gene Ontology Cellular Component:
- cell surface
endosome
integral component of membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
G-protein coupled receptor
Leucine-rich repeat
Membrane
Receptor
Reference proteome
Repeat
Signal
Transducer
Transmembrane
Transmembrane helix
Publication
- PubMed ID:
- 15815621