Names & Taxonomy
- Uniprot ID:
- Q16877
- Entry Name:
- F264_HUMAN
- Status:
- reviewed
- Protein Names:
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase 4) (PFK/FBPase 4) (6PF-2-K/Fru-2,6-P2ase testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]
- Gene Names:
- PFKFB4
- Gene Names Primary:
- PFKFB4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 469
- Sequence:
- MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ
- Proteomes:
- UP000005640
Function
- Function:
- Synthesis and degradation of fructose 2,6-bisphosphate.
- Catalytic Activity:
- Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.; ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.
- Enzyme Regulation:
- ENZYME REGULATION: The most important regulatory mechanism of these opposing activities is by phosphorylation and dephosphorylation of the enzyme.
- Active Site:
- ACT_SITE 129 129
- Gene Ontology Go:
- cytosol
6-phosphofructo-2-kinase activity
ATP binding
fructose-2,6-bisphosphate 2-phosphatase activity
canonical glycolysis
carbohydrate metabolic process
carbohydrate phosphorylation
fructose 2,6-bisphosphate metabolic process
fructose metabolic process
glucose metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- canonical glycolysis
carbohydrate metabolic process
carbohydrate phosphorylation
fructose 2,6-bisphosphate metabolic process
fructose metabolic process
glucose metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- 6-phosphofructo-2-kinase activity
ATP binding
fructose-2,6-bisphosphate 2-phosphatase activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Hydrolase
Kinase
Multifunctional enzyme
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase