Names & Taxonomy
- Uniprot ID:
- Q16854
- Entry Name:
- DGUOK_HUMAN
- Status:
- reviewed
- Protein Names:
- Deoxyguanosine kinase, mitochondrial (dGK) (EC 2.7.1.113)
- Gene Names:
- DGUOK DGK
- Gene Names Primary:
- DGUOK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 277
- Sequence:
- MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTKTYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLKVQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
- Catalytic Activity:
- ATP + deoxyguanosine = ADP + dGMP.
- Active Site:
- ACT_SITE 141 141 Proton acceptor.
- Cross Reference Drug Bank:
- DB01280
- Gene Ontology Go:
- cytosol
mitochondrial matrix
mitochondrion
nucleus
ATP binding
deoxyguanosine kinase activity
nucleoside kinase activity
deoxyribonucleoside monophosphate biosynthetic process
dGTP metabolic process
guanosine metabolic process
negative regulation of neuron projection development
nucleobase-containing small molecule metabolic process
nucleotide biosynthetic process
protein phosphorylation
purine deoxyribonucleoside metabolic process
purine nucleobase metabolic process
purine-containing compound salvage
small molecule metabolic process - Gene Ontology Biological Process:
- deoxyribonucleoside monophosphate biosynthetic process
dGTP metabolic process
guanosine metabolic process
negative regulation of neuron projection development
nucleobase-containing small molecule metabolic process
nucleotide biosynthetic process
protein phosphorylation
purine-containing compound salvage
purine deoxyribonucleoside metabolic process
purine nucleobase metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
deoxyguanosine kinase activity
nucleoside kinase activity - Gene Ontology Cellular Component:
- cytosol
mitochondrial matrix
mitochondrion
nucleus - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Kinase
Mitochondrion
Neuropathy
Nucleotide-binding
Reference proteome
Transferase
Transit peptide