Names & Taxonomy
- Uniprot ID:
- Q16842
- Entry Name:
- SIA4B_HUMAN
- Status:
- reviewed
- Protein Names:
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 (Alpha 2,3-ST 2) (Beta-galactoside alpha-2,3-sialyltransferase 2) (EC 2.4.99.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (ST3Gal II) (ST3GalII) (ST3GalA.2) (Sialyltransferase 4B) (SIAT4-B)
- Gene Names:
- ST3GAL2 SIAT4B
- Gene Names Primary:
- ST3GAL2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 350
- Sequence:
- MKCSLRVWFLSVAFLLVFIMSLLFTYSHHSMATLPYLDSGALDGTHRVKLVPGYAGLQRLSKERLSGKSCACRRCMGDAGASDWFDSHFDGNISPVWTRENMDLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVLDLLWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYRGN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus, Golgi stack membrane
Function
- Function:
- It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.
- Pathway:
- Protein modification; protein glycosylation.
- Catalytic Activity:
- CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R.
- Gene Ontology Go:
- extracellular region
Golgi cisterna membrane
Golgi membrane
integral component of Golgi membrane
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
amino sugar metabolic process
carbohydrate metabolic process
cellular protein metabolic process
cellular protein modification process
dolichol-linked oligosaccharide biosynthetic process
ganglioside biosynthetic process
glycosaminoglycan metabolic process
keratan sulfate biosynthetic process
keratan sulfate metabolic process
O-glycan processing
oligosaccharide metabolic process
post-translational protein modification
protein N-linked glycosylation via asparagine
protein O-linked glycosylation
small molecule metabolic process - Gene Ontology Biological Process:
- amino sugar metabolic process
carbohydrate metabolic process
cellular protein metabolic process
cellular protein modification process
dolichol-linked oligosaccharide biosynthetic process
ganglioside biosynthetic process
glycosaminoglycan metabolic process
keratan sulfate biosynthetic process
keratan sulfate metabolic process
O-glycan processing
oligosaccharide metabolic process
post-translational protein modification
protein N-linked glycosylation via asparagine
protein O-linked glycosylation
small molecule metabolic process - Gene Ontology Molecular Function:
- beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
- Gene Ontology Cellular Component:
- extracellular region
Golgi cisterna membrane
Golgi membrane
integral component of Golgi membrane - Keywords:
- Complete proteome
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Membrane
Reference proteome
Secreted
Signal-anchor
Transferase
Transmembrane
Transmembrane helix