Names & Taxonomy
- Uniprot ID:
- Q16832
- Entry Name:
- DDR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
- Gene Names:
- DDR2 NTRKR3 TKT TYRO10
- Gene Names Primary:
- DDR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 855
- Sequence:
- MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGDE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Present in an inactive state in the absence of collagen binding and phosphorylation by SRC. Tyrosine phosphorylation enhances the affinity for ATP and the catalytic activity.
- Active Site:
- ACT_SITE 710 710 Proton acceptor.
- Cross Reference Drug Bank:
- DB08896
- Gene Ontology Go:
- extracellular exosome
focal adhesion
integral component of plasma membrane
plasma membrane
ATP binding
collagen binding
protein tyrosine kinase collagen receptor activity
transmembrane receptor protein tyrosine kinase activity
biomineral tissue development
cell adhesion
chondrocyte proliferation
collagen fibril organization
collagen-activated tyrosine kinase receptor signaling pathway
endochondral bone growth
extracellular matrix organization
ossification
peptidyl-tyrosine phosphorylation
positive regulation of extracellular matrix disassembly
positive regulation of fibroblast migration
positive regulation of fibroblast proliferation
positive regulation of osteoblast differentiation
positive regulation of protein kinase activity
positive regulation of sequence-specific DNA binding transcription factor activity
protein autophosphorylation
regulation of bone mineralization
regulation of extracellular matrix disassembly
signal transduction - Gene Ontology Biological Process:
- biomineral tissue development
cell adhesion
chondrocyte proliferation
collagen-activated tyrosine kinase receptor signaling pathway
collagen fibril organization
endochondral bone growth
extracellular matrix organization
ossification
peptidyl-tyrosine phosphorylation
positive regulation of extracellular matrix disassembly
positive regulation of fibroblast migration
positive regulation of fibroblast proliferation
positive regulation of osteoblast differentiation
positive regulation of protein kinase activity
positive regulation of sequence-specific DNA binding transcription factor activity
protein autophosphorylation
regulation of bone mineralization
regulation of extracellular matrix disassembly
signal transduction - Gene Ontology Molecular Function:
- ATP binding
collagen binding
protein tyrosine kinase collagen receptor activity
transmembrane receptor protein tyrosine kinase activity - Gene Ontology Cellular Component:
- extracellular exosome
focal adhesion
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Dwarfism
Glycoprotein
Kinase
Membrane
Nucleotide-binding
Osteogenesis
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase - Interacts With:
- P13942; P08238