Names & Taxonomy
- Uniprot ID:
- Q16822
- Entry Name:
- PCKGM_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32)
- Gene Names:
- PCK2 PEPCK2
- Gene Names Primary:
- PCK2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 640
- Sequence:
- MAALYRPGLRLNWHGLSPLGWPSCRSIQTLRVLSGDLGQLPTGIRDFVEHSARLCQPEGIHICDGTEAENTATLTLLEQQGLIRKLPKYNNCWLARTDPKDVARVESKTVIVTPSQRDTVQLPPGGARGQLGNWMSPADFQRAVDERFPGCMQGRTMYVLPFSMGPVGSPLSRIGVQLTDSAYVVASMRIMTRLGTPVLQALGDGDFVKCLHSVGQPLTGQGEPVSQWPCNPEKTLIGHVPDQREIISFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITSPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGRLRAINPENGFFGVAPGTSATTNPNAMATIQSNTIFTNVAETSDGGVYWEGIDQPLPPGVTVTSWLGKPWKPGDKEPCAHPNSRFCAPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGSAMRSESTAAAEHKGKIIMHDPFAMRPFFGYNFGHYLEHWLSMEGRKGAQLPRIFHVNWFRRDEAGHFLWPGFGENARVLDWICRRLEGEDSARETPIGLVPKEGALDLSGLRAIDTTQLFSLPKDFWEQEVRDIRSYLTEQVNQDLPKEVLAELEALERRVHKM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
- Pathway:
- Carbohydrate biosynthesis; gluconeogenesis.
- Catalytic Activity:
- GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO(2).
- Cofactor:
- COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Active Site:
- ACT_SITE 306 306
- Gene Ontology Go:
- extracellular exosome
mitochondrial matrix
mitochondrion
GTP binding
metal ion binding
phosphoenolpyruvate carboxykinase (GTP) activity
phosphoenolpyruvate carboxykinase activity
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- GTP binding
metal ion binding
phosphoenolpyruvate carboxykinase (GTP) activity
phosphoenolpyruvate carboxykinase activity - Gene Ontology Cellular Component:
- extracellular exosome
mitochondrial matrix
mitochondrion - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Decarboxylase
GTP-binding
Gluconeogenesis
Lyase
Manganese
Metal-binding
Mitochondrion
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide - Interacts With:
- P84022