Names & Taxonomy

Uniprot ID:
Q16773
Entry Name:
KAT1_HUMAN
Status:
reviewed
Protein Names:
Kynurenine--oxoglutarate transaminase 1 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase) (EC 4.4.1.13) (Glutamine transaminase K) (GTK) (Glutamine--phenylpyruvate transaminase) (EC 2.6.1.64) (Kynurenine aminotransferase I) (KATI) (Kynurenine--oxoglutarate transaminase I)
Gene Names:
CCBL1
Gene Names Primary:
CCBL1
Organism:
Homo sapiens (Human)

Structure

Length:
422
Sequence:
MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKVEL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.
Pathway:
Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2.
Catalytic Activity:
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
Cofactor:
COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Enzyme Regulation:
ENZYME REGULATION: Inhibited by tryptophan, indole-3-pyruvic acid, 3-indolepropionic acid, DL-indole-3-lactic acid, indole-3-acetic acid (IAC) and Tris.
Cross Reference Drug Bank:
DB00130
Gene Ontology Go:
cytoplasm
cytosol
nucleoplasm
cysteine-S-conjugate beta-lyase activity
glutamine-phenylpyruvate transaminase activity
kynurenine-oxoglutarate transaminase activity
L-glutamine:pyruvate aminotransferase activity
L-phenylalanine:pyruvate aminotransferase activity
protein homodimerization activity
pyridoxal phosphate binding
transaminase activity
cellular amino acid biosynthetic process
cellular modified amino acid metabolic process
cellular nitrogen compound metabolic process
kynurenine metabolic process
L-kynurenine catabolic process
L-phenylalanine catabolic process
small molecule metabolic process
tryptophan catabolic process
Gene Ontology Biological Process:
cellular amino acid biosynthetic process
cellular modified amino acid metabolic process
cellular nitrogen compound metabolic process
kynurenine metabolic process
L-kynurenine catabolic process
L-phenylalanine catabolic process
small molecule metabolic process
tryptophan catabolic process
Gene Ontology Molecular Function:
cysteine-S-conjugate beta-lyase activity
glutamine-phenylpyruvate transaminase activity
kynurenine-oxoglutarate transaminase activity
L-glutamine:pyruvate aminotransferase activity
L-phenylalanine:pyruvate aminotransferase activity
protein homodimerization activity
pyridoxal phosphate binding
transaminase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
nucleoplasm
Keywords:
3D-structure
Alternative splicing
Aminotransferase
Complete proteome
Cytoplasm
Lyase
Pyridoxal phosphate
Reference proteome
Transferase
Interacts With:
Q15645; Q08AM6

Publication

PubMed ID:
7883047 15164053 15489334 15364907 19338303