Names & Taxonomy
- Uniprot ID:
- Q16773
- Entry Name:
- KAT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Kynurenine--oxoglutarate transaminase 1 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase) (EC 4.4.1.13) (Glutamine transaminase K) (GTK) (Glutamine--phenylpyruvate transaminase) (EC 2.6.1.64) (Kynurenine aminotransferase I) (KATI) (Kynurenine--oxoglutarate transaminase I)
- Gene Names:
- CCBL1
- Gene Names Primary:
- CCBL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 422
- Sequence:
- MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKVEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.
- Pathway:
- Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2.
- Catalytic Activity:
- L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by tryptophan, indole-3-pyruvic acid, 3-indolepropionic acid, DL-indole-3-lactic acid, indole-3-acetic acid (IAC) and Tris.
- Cross Reference Drug Bank:
- DB00130
- Gene Ontology Go:
- cytoplasm
cytosol
nucleoplasm
cysteine-S-conjugate beta-lyase activity
glutamine-phenylpyruvate transaminase activity
kynurenine-oxoglutarate transaminase activity
L-glutamine:pyruvate aminotransferase activity
L-phenylalanine:pyruvate aminotransferase activity
protein homodimerization activity
pyridoxal phosphate binding
transaminase activity
cellular amino acid biosynthetic process
cellular modified amino acid metabolic process
cellular nitrogen compound metabolic process
kynurenine metabolic process
L-kynurenine catabolic process
L-phenylalanine catabolic process
small molecule metabolic process
tryptophan catabolic process - Gene Ontology Biological Process:
- cellular amino acid biosynthetic process
cellular modified amino acid metabolic process
cellular nitrogen compound metabolic process
kynurenine metabolic process
L-kynurenine catabolic process
L-phenylalanine catabolic process
small molecule metabolic process
tryptophan catabolic process - Gene Ontology Molecular Function:
- cysteine-S-conjugate beta-lyase activity
glutamine-phenylpyruvate transaminase activity
kynurenine-oxoglutarate transaminase activity
L-glutamine:pyruvate aminotransferase activity
L-phenylalanine:pyruvate aminotransferase activity
protein homodimerization activity
pyridoxal phosphate binding
transaminase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleoplasm - Keywords:
- 3D-structure
Alternative splicing
Aminotransferase
Complete proteome
Cytoplasm
Lyase
Pyridoxal phosphate
Reference proteome
Transferase - Interacts With:
- Q15645; Q08AM6