Names & Taxonomy
- Uniprot ID:
- Q16769
- Entry Name:
- QPCT_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC)
- Gene Names:
- QPCT
- Gene Names Primary:
- QPCT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 361
- Sequence:
- MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides -beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
- Catalytic Activity:
- L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3).
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 201 201 Proton acceptor.
- Gene Ontology Go:
- extracellular exosome
glutaminyl-peptide cyclotransferase activity
zinc ion binding
cellular protein modification process
peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase - Gene Ontology Biological Process:
- cellular protein modification process
peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase - Gene Ontology Molecular Function:
- glutaminyl-peptide cyclotransferase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular exosome
- Keywords:
- 3D-structure
Acyltransferase
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal
Transferase
Zinc