Names & Taxonomy
- Uniprot ID:
- Q16740
- Entry Name:
- CLPP_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-dependent Clp protease proteolytic subunit, mitochondrial (EC 3.4.21.92) (Endopeptidase Clp)
- Gene Names:
- CLPP
- Gene Names Primary:
- CLPP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 277
- Sequence:
- MWPGILVGGARVASCRYPALGPRLAAHFPAQRPPQRTLQNGLALQRCLHATATRALPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPTLVQKEPVEAAPAAEPVPAST
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Function:
- Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.
- Catalytic Activity:
- Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
- Active Site:
- ACT_SITE 153 153 Nucleophile.
- Gene Ontology Go:
- endopeptidase Clp complex
mitochondrial matrix
mitochondrion
peptidase activity
serine-type endopeptidase activity
protein homooligomerization
proteolysis involved in cellular protein catabolic process - Gene Ontology Biological Process:
- protein homooligomerization
proteolysis involved in cellular protein catabolic process - Gene Ontology Molecular Function:
- peptidase activity
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- endopeptidase Clp complex
mitochondrial matrix
mitochondrion - Keywords:
- 3D-structure
Acetylation
Complete proteome
Deafness
Direct protein sequencing
Disease mutation
Hydrolase
Mitochondrion
Protease
Reference proteome
Serine protease
Transit peptide