Names & Taxonomy
- Uniprot ID:
- Q16706
- Entry Name:
- MA2A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)
- Gene Names:
- MAN2A1 MANA2
- Gene Names Primary:
- MAN2A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1144
- Sequence:
- MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLERLLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFASQSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMTKEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQIQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPMANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFSSKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFRIQLR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus membrane
Function
- Function:
- Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
- Pathway:
- Protein modification; protein glycosylation.
- Catalytic Activity:
- Hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3).
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 289 289 Nucleophile.
- Gene Ontology Go:
- cis-Golgi network
extracellular exosome
Golgi membrane
integral component of membrane
membrane
carbohydrate binding
hydrolase activity, hydrolyzing N-glycosyl compounds
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
zinc ion binding
cellular protein metabolic process
in utero embryonic development
liver development
lung alveolus development
mannose metabolic process
mitochondrion organization
N-glycan processing
positive regulation of neurogenesis
post-translational protein modification
protein deglycosylation
protein N-linked glycosylation via asparagine
respiratory gaseous exchange
retina morphogenesis in camera-type eye
vacuole organization - Gene Ontology Biological Process:
- cellular protein metabolic process
in utero embryonic development
liver development
lung alveolus development
mannose metabolic process
mitochondrion organization
N-glycan processing
positive regulation of neurogenesis
post-translational protein modification
protein deglycosylation
protein N-linked glycosylation via asparagine
respiratory gaseous exchange
retina morphogenesis in camera-type eye
vacuole organization - Gene Ontology Molecular Function:
- carbohydrate binding
hydrolase activity, hydrolyzing N-glycosyl compounds
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
zinc ion binding - Gene Ontology Cellular Component:
- cis-Golgi network
extracellular exosome
Golgi membrane
integral component of membrane
membrane - Keywords:
- Complete proteome
Disulfide bond
Glycoprotein
Glycosidase
Golgi apparatus
Hydrolase
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix
Zinc