Names & Taxonomy
- Uniprot ID:
- Q16696
- Entry Name:
- CP2AD_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome P450 2A13 (EC 1.14.14.1) (CYPIIA13)
- Gene Names:
- CYP2A13
- Gene Names Primary:
- CYP2A13
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 494
- Sequence:
- MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYTMSFLPR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Function
- Function:
- Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.
- Catalytic Activity:
- RH + + O(2) = ROH + + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=10.7 uM for phenacetin
- Cross Reference Drug Bank:
- DB00553 DB00184 DB00624
- Gene Ontology Go:
- endoplasmic reticulum membrane
arachidonic acid epoxygenase activity
aromatase activity
heme binding
iron ion binding
steroid hydroxylase activity
epoxygenase P450 pathway
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- epoxygenase P450 pathway
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- arachidonic acid epoxygenase activity
aromatase activity
heme binding
iron ion binding
steroid hydroxylase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
- Keywords:
- 3D-structure
Complete proteome
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
Oxidoreductase
Polymorphism
Reference proteome