Names & Taxonomy
- Uniprot ID:
- Q16658
- Entry Name:
- FSCN1_HUMAN
- Status:
- reviewed
- Protein Names:
- Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55)
- Gene Names:
- FSCN1 FAN1 HSN SNL
- Gene Names Primary:
- FSCN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 493
- Sequence:
- MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol
Function
- Function:
- Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.
- Gene Ontology Go:
- actin cytoskeleton
cell projection membrane
cell-cell junction
cytoplasm
cytoskeleton
cytosol
extracellular exosome
filopodium
growth cone
invadopodium
lamellipodium
microspike
microvillus
myelin sheath
podosome
ruffle
stress fiber
actin binding
actin filament binding
drug binding
poly(A) RNA binding
actin cytoskeleton organization
actin filament bundle assembly
cell migration
cell motility
cell proliferation
cell-cell junction assembly
establishment of apical/basal cell polarity
microspike assembly
positive regulation of extracellular matrix disassembly
positive regulation of filopodium assembly
positive regulation of lamellipodium assembly
positive regulation of podosome assembly
regulation of actin cytoskeleton organization
regulation of microvillus assembly - Gene Ontology Biological Process:
- actin cytoskeleton organization
actin filament bundle assembly
cell-cell junction assembly
cell migration
cell motility
cell proliferation
establishment of apical/basal cell polarity
microspike assembly
positive regulation of extracellular matrix disassembly
positive regulation of filopodium assembly
positive regulation of lamellipodium assembly
positive regulation of podosome assembly
regulation of actin cytoskeleton organization
regulation of microvillus assembly - Gene Ontology Molecular Function:
- actin binding
actin filament binding
drug binding
poly(A) RNA binding - Gene Ontology Cellular Component:
- actin cytoskeleton
cell-cell junction
cell projection membrane
cytoplasm
cytoskeleton
cytosol
extracellular exosome
filopodium
growth cone
invadopodium
lamellipodium
microspike
microvillus
myelin sheath
podosome
ruffle
stress fiber - Keywords:
- 3D-structure
Acetylation
Actin-binding
Cell junction
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Isopeptide bond
Phosphoprotein
Reference proteome
Ubl conjugation - Interacts With:
- Q9BXW9; P40692; Q9ULL4; P63104