Names & Taxonomy

Uniprot ID:
Q16322
Entry Name:
KCA10_HUMAN
Status:
reviewed
Protein Names:
Potassium voltage-gated channel subfamily A member 10 (Voltage-gated potassium channel subunit Kv1.8)
Gene Names:
KCNA10
Gene Names Primary:
KCNA10
Organism:
Homo sapiens (Human)

Structure

Length:
511
Sequence:
MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSRK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.
Cross Reference Drug Bank:
DB06637
Gene Ontology Go:
integral component of membrane
plasma membrane
voltage-gated potassium channel complex
delayed rectifier potassium channel activity
intracellular cyclic nucleotide activated cation channel activity
potassium ion transport
protein homooligomerization
synaptic transmission
Gene Ontology Biological Process:
potassium ion transport
protein homooligomerization
synaptic transmission
Gene Ontology Molecular Function:
delayed rectifier potassium channel activity
intracellular cyclic nucleotide activated cation channel activity
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
voltage-gated potassium channel complex
Keywords:
Complete proteome
Glycoprotein
Ion channel
Ion transport
Lipoprotein
Membrane
Palmitate
Polymorphism
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel

Publication

PubMed ID:
9177773 16710414 15489334 10836990 12060596 12444201 16959974