Names & Taxonomy
- Uniprot ID:
- Q16322
- Entry Name:
- KCA10_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium voltage-gated channel subfamily A member 10 (Voltage-gated potassium channel subunit Kv1.8)
- Gene Names:
- KCNA10
- Gene Names Primary:
- KCNA10
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 511
- Sequence:
- MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSRK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.
- Cross Reference Drug Bank:
- DB06637
- Gene Ontology Go:
- integral component of membrane
plasma membrane
voltage-gated potassium channel complex
delayed rectifier potassium channel activity
intracellular cyclic nucleotide activated cation channel activity
potassium ion transport
protein homooligomerization
synaptic transmission - Gene Ontology Biological Process:
- potassium ion transport
protein homooligomerization
synaptic transmission - Gene Ontology Molecular Function:
- delayed rectifier potassium channel activity
intracellular cyclic nucleotide activated cation channel activity - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane
voltage-gated potassium channel complex - Keywords:
- Complete proteome
Glycoprotein
Ion channel
Ion transport
Lipoprotein
Membrane
Palmitate
Polymorphism
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel