Names & Taxonomy

Uniprot ID:
Q16288
Entry Name:
NTRK3_HUMAN
Status:
reviewed
Protein Names:
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene Names:
NTRK3 TRKC
Gene Names Primary:
NTRK3
Organism:
Homo sapiens (Human)

Structure

Length:
839
Sequence:
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Catalytic Activity:
ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
Active Site:
ACT_SITE 679 679 Proton acceptor.
Gene Ontology Go:
cytoplasm
integral component of plasma membrane
receptor complex
ATP binding
GPI-linked ephrin receptor activity
neurotrophin binding
neurotrophin receptor activity
p53 binding
activation of GTPase activity
activation of MAPK activity
activation of protein kinase B activity
cellular response to retinoic acid
circadian rhythm
cochlea development
heart development
lens fiber cell differentiation
mechanoreceptor differentiation
modulation by virus of host transcription
negative regulation of astrocyte differentiation
negative regulation of cell death
negative regulation of protein phosphorylation
neuron fate specification
neuron migration
positive regulation of actin cytoskeleton reorganization
positive regulation of apoptotic process
positive regulation of axon extension involved in regeneration
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of peptidyl-serine phosphorylation
positive regulation of positive chemotaxis
positive regulation of protein phosphorylation
positive regulation of synapse assembly
protein autophosphorylation
response to axon injury
response to corticosterone
response to ethanol
transmembrane receptor protein tyrosine kinase signaling pathway
Gene Ontology Biological Process:
activation of GTPase activity
activation of MAPK activity
activation of protein kinase B activity
cellular response to retinoic acid
circadian rhythm
cochlea development
heart development
lens fiber cell differentiation
mechanoreceptor differentiation
modulation by virus of host transcription
negative regulation of astrocyte differentiation
negative regulation of cell death
negative regulation of protein phosphorylation
neuron fate specification
neuron migration
positive regulation of actin cytoskeleton reorganization
positive regulation of apoptotic process
positive regulation of axon extension involved in regeneration
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of peptidyl-serine phosphorylation
positive regulation of positive chemotaxis
positive regulation of protein phosphorylation
positive regulation of synapse assembly
protein autophosphorylation
response to axon injury
response to corticosterone
response to ethanol
transmembrane receptor protein tyrosine kinase signaling pathway
Gene Ontology Molecular Function:
ATP binding
GPI-linked ephrin receptor activity
neurotrophin binding
neurotrophin receptor activity
p53 binding
Gene Ontology Cellular Component:
cytoplasm
integral component of plasma membrane
receptor complex
Keywords:
3D-structure
ATP-binding
Alternative splicing
Complete proteome
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Kinase
Leucine-rich repeat
Membrane
Neurogenesis
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase
Interacts With:
Q99523

Publication

PubMed ID:
7806211 7823156 9778053 14702039 16572171 25196463 10388563 17344846 18293376