Names & Taxonomy
- Uniprot ID:
- Q16280
- Entry Name:
- CNGA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (Cyclic nucleotide-gated channel alpha-2) (CNG channel alpha-2) (CNG-2) (CNG2)
- Gene Names:
- CNGA2 CNCA CNCA1 CNCG2
- Gene Names Primary:
- CNGA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 664
- Sequence:
- MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGEDKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAAADEP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
- Gene Ontology Go:
- ciliary membrane
Golgi membrane
Golgi-associated vesicle membrane
integral component of membrane
cAMP binding
cGMP binding
intracellular cAMP activated cation channel activity
intracellular cGMP activated cation channel activity
voltage-gated potassium channel activity
cation transmembrane transport
organelle organization
potassium ion transmembrane transport
regulation of membrane potential
response to stimulus
sensory perception of smell - Gene Ontology Biological Process:
- cation transmembrane transport
organelle organization
potassium ion transmembrane transport
regulation of membrane potential
response to stimulus
sensory perception of smell - Gene Ontology Molecular Function:
- cAMP binding
cGMP binding
intracellular cAMP activated cation channel activity
intracellular cGMP activated cation channel activity
voltage-gated potassium channel activity - Gene Ontology Cellular Component:
- ciliary membrane
Golgi-associated vesicle membrane
Golgi membrane
integral component of membrane - Keywords:
- Calmodulin-binding
Coiled coil
Complete proteome
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Nucleotide-binding
Olfaction
Polymorphism
Reference proteome
Sensory transduction
Transmembrane
Transmembrane helix
Transport
cAMP
cAMP-binding