Names & Taxonomy

Uniprot ID:
Q16280
Entry Name:
CNGA2_HUMAN
Status:
reviewed
Protein Names:
Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (Cyclic nucleotide-gated channel alpha-2) (CNG channel alpha-2) (CNG-2) (CNG2)
Gene Names:
CNGA2 CNCA CNCA1 CNCG2
Gene Names Primary:
CNGA2
Organism:
Homo sapiens (Human)

Structure

Length:
664
Sequence:
MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGEDKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAAADEP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
Gene Ontology Go:
ciliary membrane
Golgi membrane
Golgi-associated vesicle membrane
integral component of membrane
cAMP binding
cGMP binding
intracellular cAMP activated cation channel activity
intracellular cGMP activated cation channel activity
voltage-gated potassium channel activity
cation transmembrane transport
organelle organization
potassium ion transmembrane transport
regulation of membrane potential
response to stimulus
sensory perception of smell
Gene Ontology Biological Process:
cation transmembrane transport
organelle organization
potassium ion transmembrane transport
regulation of membrane potential
response to stimulus
sensory perception of smell
Gene Ontology Molecular Function:
cAMP binding
cGMP binding
intracellular cAMP activated cation channel activity
intracellular cGMP activated cation channel activity
voltage-gated potassium channel activity
Gene Ontology Cellular Component:
ciliary membrane
Golgi-associated vesicle membrane
Golgi membrane
integral component of membrane
Keywords:
Calmodulin-binding
Coiled coil
Complete proteome
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Nucleotide-binding
Olfaction
Polymorphism
Reference proteome
Sensory transduction
Transmembrane
Transmembrane helix
Transport
cAMP
cAMP-binding

Publication

PubMed ID:
15489334 7532814 16959974