Names & Taxonomy
- Uniprot ID:
- Q16270
- Entry Name:
- IBP7_HUMAN
- Status:
- reviewed
- Protein Names:
- Insulin-like growth factor-binding protein 7 (IBP-7) (IGF-binding protein 7) (IGFBP-7) (IGFBP-rP1) (MAC25 protein) (PGI2-stimulating factor) (Prostacyclin-stimulating factor) (Tumor-derived adhesion factor) (TAF)
- Gene Names:
- IGFBP7 MAC25 PSF
- Gene Names Primary:
- IGFBP7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 282
- Sequence:
- MERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALHEIPVKKGEGAEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
- Cross Reference Drug Bank:
- DB00030
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
cell adhesion
negative regulation of cell proliferation
regulation of cell growth - Gene Ontology Biological Process:
- cell adhesion
negative regulation of cell proliferation
regulation of cell growth - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space - Keywords:
- Alternative splicing
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor binding
Immunoglobulin domain
Phosphoprotein
Polymorphism
RNA editing
Reference proteome
Secreted
Signal