Names & Taxonomy
- Uniprot ID:
- Q15842
- Entry Name:
- KCNJ8_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-sensitive inward rectifier potassium channel 8 (Inward rectifier K(+) channel Kir6.1) (Potassium channel, inwardly rectifying subfamily J member 8) (uKATP-1)
- Gene Names:
- KCNJ8
- Gene Names Primary:
- KCNJ8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 424
- Sequence:
- MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNIREQGRFLQDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKSGMEKSGLESTVCVTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMKTAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEVVPIHQLDIPVDNPIESNNIFLVAPLIICHVIDKRSPLYDISATDLANQDLEVIVILEGVVETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGVYSVDYSKFGNTVKVAAPRCSARELDEKPSILIQTLQKSELSHQNSLRKRNSMRRNNSMRRNNSIRRNNSSLMVPKVQFMTPEGNQNTSES
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
- Intramembrane:
- INTRAMEM 127 138 Helical; Pore-forming; Name=H5.
Function
- Function:
- This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity).
- Cross Reference Drug Bank:
- DB01251 DB01289 DB01016 DB00922 DB00914 DB01154 DB01392
- Gene Ontology Go:
- ATP-sensitive potassium channel complex
mitochondrion
myofibril
plasma membrane
sarcolemma
voltage-gated potassium channel complex
ATP binding
ATP-activated inward rectifier potassium channel activity
inward rectifier potassium channel activity
defense response to virus
heart development
kidney development
potassium ion import
potassium ion transport
response to exogenous dsRNA
response to lipopolysaccharide
response to pH
synaptic transmission
vasodilation - Gene Ontology Biological Process:
- defense response to virus
heart development
kidney development
potassium ion import
potassium ion transport
response to exogenous dsRNA
response to lipopolysaccharide
response to pH
synaptic transmission
vasodilation - Gene Ontology Molecular Function:
- ATP-activated inward rectifier potassium channel activity
ATP binding
inward rectifier potassium channel activity - Gene Ontology Cellular Component:
- ATP-sensitive potassium channel complex
mitochondrion
myofibril
plasma membrane
sarcolemma
voltage-gated potassium channel complex - Keywords:
- Complete proteome
Disease mutation
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Potassium
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel