Names & Taxonomy
- Uniprot ID:
- Q15788
- Entry Name:
- NCOA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
- Gene Names:
- NCOA1 BHLHE74 SRC1
- Gene Names Primary:
- NCOA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1441
- Sequence:
- MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAVTSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAINQSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGTMPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSFGNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEADGTQQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLTE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
- Catalytic Activity:
- Acetyl-CoA + = CoA + acetyl-.
- Gene Ontology Go:
- cytoplasm
neuron projection
nuclear chromatin
nucleoplasm
androgen receptor binding
chromatin binding
enzyme binding
histone acetyltransferase activity
ligand-dependent nuclear receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
nuclear hormone receptor binding
protein N-terminus binding
RNA polymerase II regulatory region DNA binding
RNA polymerase II transcription coactivator activity
transcription coactivator activity
androgen receptor signaling pathway
bile acid and bile salt transport
bile acid metabolic process
cellular lipid metabolic process
cellular response to hormone stimulus
cellular response to Thyroglobulin triiodothyronine
cerebellum development
cerebral cortex development
chromatin organization
estrous cycle
hippocampus development
histone H4 acetylation
hypothalamus development
labyrinthine layer morphogenesis
lactation
male gonad development
male mating behavior
positive regulation of apoptotic process
positive regulation of female receptivity
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter by galactose
positive regulation of transcription, DNA-templated
regulation of cellular response to drug
regulation of thyroid hormone mediated signaling pathway
response to estradiol
response to progesterone
response to retinoic acid
small molecule metabolic process
transcription, DNA-templated - Gene Ontology Biological Process:
- androgen receptor signaling pathway
bile acid and bile salt transport
bile acid metabolic process
cellular lipid metabolic process
cellular response to hormone stimulus
cellular response to Thyroglobulin triiodothyronine
cerebellum development
cerebral cortex development
chromatin organization
estrous cycle
hippocampus development
histone H4 acetylation
hypothalamus development
labyrinthine layer morphogenesis
lactation
male gonad development
male mating behavior
positive regulation of apoptotic process
positive regulation of female receptivity
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter by galactose
regulation of cellular response to drug
regulation of thyroid hormone mediated signaling pathway
response to estradiol
response to progesterone
response to retinoic acid
small molecule metabolic process
transcription, DNA-templated - Gene Ontology Molecular Function:
- androgen receptor binding
chromatin binding
enzyme binding
histone acetyltransferase activity
ligand-dependent nuclear receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
nuclear hormone receptor binding
protein N-terminus binding
RNA polymerase II regulatory region DNA binding
RNA polymerase II transcription coactivator activity
transcription coactivator activity - Gene Ontology Cellular Component:
- cytoplasm
neuron projection
nuclear chromatin
nucleoplasm - Keywords:
- 3D-structure
Acetylation
Activator
Acyltransferase
Alternative splicing
Chromosomal rearrangement
Complete proteome
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism
Proto-oncogene
Reference proteome
Repeat
Transcription
Transcription regulation
Transferase
Ubl conjugation - Interacts With:
- P59598; P03372; P19785; Q63ZY3; P25799; Q13133; Q96RI1; P06536; Q9BTK6; P28065; P10276; P51449; P19793
Publication
- PubMed ID:
- 8754792 9427757 9575154 15815621 15489334 7481822 11831720 15313887 9223431 9296499 9223281 10508479 10567404 10449719 10660621 10722692 10594042 11250900 11773079 12039952 12138096 12529333 12954634 12917342 15367689 16957778 16606617 17116691 17525332 19413330 19786558 20047962 20068231 25219498 9744270 11698662 11864604 14757047