Names & Taxonomy
- Uniprot ID:
- Q15758
- Entry Name:
- AAAT_HUMAN
- Status:
- reviewed
- Protein Names:
- Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5)
- Gene Names:
- SLC1A5 ASCT2 M7V1 RDR RDRC
- Gene Names Primary:
- SLC1A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 541
- Sequence:
- MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASEKESVM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).
- Cross Reference Drug Bank:
- DB00174 DB00130
- Gene Ontology Go:
- extracellular exosome
Golgi apparatus
integral component of plasma membrane
melanosome
membrane
plasma membrane
L-glutamine transmembrane transporter activity
neutral amino acid transmembrane transporter activity
receptor activity
sodium:dicarboxylate symporter activity
virus receptor activity
amino acid transport
glutamine transport
ion transport
neutral amino acid transport
transmembrane transport - Gene Ontology Biological Process:
- amino acid transport
glutamine transport
ion transport
neutral amino acid transport
transmembrane transport - Gene Ontology Molecular Function:
- L-glutamine transmembrane transporter activity
neutral amino acid transmembrane transporter activity
receptor activity
sodium:dicarboxylate symporter activity
virus receptor activity - Gene Ontology Cellular Component:
- extracellular exosome
Golgi apparatus
integral component of plasma membrane
melanosome
membrane
plasma membrane - Keywords:
- Acetylation
Alternative initiation
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Host cell receptor for virus entry
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q99942