Names & Taxonomy
- Uniprot ID:
- Q15717
- Entry Name:
- ELAV1_HUMAN
- Status:
- reviewed
- Protein Names:
- ELAV-like protein 1 (Hu-antigen R) (HuR)
- Gene Names:
- ELAVL1 HUR
- Gene Names Primary:
- ELAVL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 326
- Sequence:
- MSNGYEDHMAEDCRGDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNVALLSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUUUUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).
- Gene Ontology Go:
- cytoplasm
cytosol
membrane
nucleoplasm
nucleus
AU-rich element binding
double-stranded RNA binding
mRNA 3'-UTR AU-rich region binding
mRNA 3'-UTR binding
mRNA binding
nucleotide binding
poly(A) RNA binding
protein homodimerization activity
protein kinase binding
RNA binding
3'-UTR-mediated mRNA stabilization
gene expression
mRNA stabilization
multicellular organism development
positive regulation of translation
regulation of mRNA stability
regulation of stem cell population maintenance - Gene Ontology Biological Process:
- 3'-UTR-mediated mRNA stabilization
gene expression
mRNA stabilization
multicellular organism development
positive regulation of translation
regulation of mRNA stability
regulation of stem cell population maintenance - Gene Ontology Molecular Function:
- AU-rich element binding
double-stranded RNA binding
mRNA 3'-UTR AU-rich region binding
mRNA 3'-UTR binding
mRNA binding
nucleotide binding
poly(A) RNA binding
protein homodimerization activity
protein kinase binding
RNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
membrane
nucleoplasm
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Methylation
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Repeat - Interacts With:
- O00560; P0CG48