Names & Taxonomy
- Uniprot ID:
- Q15382
- Entry Name:
- RHEB_HUMAN
- Status:
- reviewed
- Protein Names:
- GTP-binding protein Rheb (Ras homolog enriched in brain)
- Gene Names:
- RHEB RHEB2
- Gene Names Primary:
- RHEB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 184
- Sequence:
- MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endomembrane system
Function
- Function:
- Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
- Enzyme Regulation:
- ENZYME REGULATION: Alternates between an inactive form bound to GDP and an active form bound to GTP. Inactivated by TSC1-TSC2 via the GTPase activating protein (GAP) domain of TSC2.
- Gene Ontology Go:
- cytosol
endoplasmic reticulum membrane
extracellular exosome
Golgi membrane
lysosomal membrane
membrane
spliceosomal complex
GTP binding
GTPase activity
metal ion binding
cell cycle arrest
gene expression
insulin receptor signaling pathway
macroautophagy
positive regulation of oligodendrocyte differentiation
positive regulation of TOR signaling
regulation of type B pancreatic cell development
signal transduction
small GTPase mediated signal transduction
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- cell cycle arrest
gene expression
insulin receptor signaling pathway
macroautophagy
positive regulation of oligodendrocyte differentiation
positive regulation of TOR signaling
regulation of type B pancreatic cell development
signal transduction
small GTPase mediated signal transduction
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
metal ion binding - Gene Ontology Cellular Component:
- cytosol
endoplasmic reticulum membrane
extracellular exosome
Golgi membrane
lysosomal membrane
membrane
spliceosomal complex - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Endoplasmic reticulum
GTP-binding
Golgi apparatus
Lipoprotein
Magnesium
Membrane
Metal-binding
Methylation
Nucleotide-binding
Phosphoprotein
Polymorphism
Prenylation
Reference proteome - Interacts With:
- O43924