Names & Taxonomy
- Uniprot ID:
- Q15274
- Entry Name:
- NADC_HUMAN
- Status:
- reviewed
- Protein Names:
- Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (QPRTase)
- Gene Names:
- QPRT
- Gene Names Primary:
- QPRT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 297
- Sequence:
- MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFTLKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH
- Proteomes:
- UP000005640
Function
- Function:
- Involved in the catabolism of quinolinic acid (QA).
- Pathway:
- Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.
- Catalytic Activity:
- Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=21 uM for QA (at 0.1 mM PRPP)
- Enzyme Regulation:
- ENZYME REGULATION: Activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner.
- Cross Reference Drug Bank:
- DB00627
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nicotinate-nucleotide diphosphorylase (carboxylating) activity
protein homodimerization activity
NAD biosynthetic process
NAD metabolic process
protein oligomerization
quinolinate catabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- NAD biosynthetic process
NAD metabolic process
protein oligomerization
quinolinate catabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- nicotinate-nucleotide diphosphorylase (carboxylating) activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome - Keywords:
- 3D-structure
Complete proteome
Glycosyltransferase
Polymorphism
Pyridine nucleotide biosynthesis
Reference proteome
Transferase