Names & Taxonomy
- Uniprot ID:
- Q14994
- Entry Name:
- NR1I3_HUMAN
- Status:
- reviewed
- Protein Names:
- Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67)
- Gene Names:
- NR1I3 CAR
- Gene Names Primary:
- NR1I3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 352
- Sequence:
- MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7.
Function
- Function:
- Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
- Gene Ontology Go:
- cytoplasm
cytoskeleton
cytosol
nucleoplasm
nucleus
androgen receptor activity
DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
thyroid hormone receptor activity
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
zinc ion binding
androgen receptor signaling pathway
gene expression
intracellular receptor signaling pathway
negative regulation of transcription, DNA-templated
osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
signal transduction
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- androgen receptor signaling pathway
gene expression
intracellular receptor signaling pathway
negative regulation of transcription, DNA-templated
osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
signal transduction
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- androgen receptor activity
DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
thyroid hormone receptor activity
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytoskeleton
cytosol
nucleoplasm
nucleus - Keywords:
- 3D-structure
Activator
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
DNA-binding
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transcription
Transcription regulation
Zinc
Zinc-finger