Names & Taxonomy
- Uniprot ID:
- Q14916
- Entry Name:
- NPT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium-dependent phosphate transport protein 1 (Na(+)/PI cotransporter 1) (Na/Pi-4) (Renal Na(+)-dependent phosphate cotransporter 1) (Renal sodium-dependent phosphate transport protein 1) (Renal sodium-phosphate transport protein 1) (Sodium/phosphate cotransporter 1) (Solute carrier family 17 member 1)
- Gene Names:
- SLC17A1 NPT1
- Gene Names Primary:
- SLC17A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 467
- Sequence:
- MQMDNRLPPKKVPGFCSFRYGLSFLVHCCNVIITAQRACLNLTMVVMVNSTDPHGLPNTSTKKLLDNIKNPMYNWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIGVAWVVVCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFVLFYDDPKDHPCISISEKEYITSSLVQQVSSSRQSLPIKAILKSLPVWAISTGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVIAVRKLFTAAGFLLPAIFGVCLPYLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIAPRYFGFIKACSTLTGMIGGLIASTLTGLILKQDPESAWFKTFILMAAINVTGLIFYLIVATAEIQDWAKEKQHTRL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane.
- Gene Ontology Go:
- integral component of plasma membrane
membrane
plasma membrane
sodium-dependent phosphate transmembrane transporter activity
sodium:phosphate symporter activity
ion transport
phosphate ion transport
sodium ion transmembrane transport
sodium-dependent phosphate transport
transmembrane transport
urate metabolic process - Gene Ontology Biological Process:
- ion transport
phosphate ion transport
sodium-dependent phosphate transport
sodium ion transmembrane transport
transmembrane transport
urate metabolic process - Gene Ontology Molecular Function:
- sodium:phosphate symporter activity
sodium-dependent phosphate transmembrane transporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport