Names & Taxonomy
- Uniprot ID:
- Q14914
- Entry Name:
- PTGR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Prostaglandin reductase 1 (PRG-1) (EC 1.3.1.-) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (NADP-dependent leukotriene B4 12-hydroxydehydrogenase) (EC 1.3.1.74)
- Gene Names:
- PTGR1 LTB4DH
- Gene Names Primary:
- PTGR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 329
- Sequence:
- MVRTKTWTLKKHFVGYPTNSDFELKTAELPPLKNGEVLLEALFLTVDPYMRVAAKRLKEGDTMMGQQVAKVVESKNVALPKGTIVLASPGWTTHSISDGKDLEKLLTEWPDTIPLSLALGTVGMPGLTAYFGLLEICGVKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAVGSDEKVAYLQKLGFDVVFNYKTVESLEETLKKASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIAICGAISTYNRTGPLPPGPPPEIVIYQELRMEAFVVYRWQGDARQKALKDLLKWVLEGKIQYKEYIIEGFENMPAAFMGMLKGDNLGKTIVKA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.
- Catalytic Activity:
- A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H.; 11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.
- Gene Ontology Go:
- cytoplasm
extracellular exosome
13-prostaglandin reductase activity
15-oxoprostaglandin 13-oxidase activity
2-alkenal reductase activity
zinc ion binding
arachidonic acid metabolic process
cyclooxygenase pathway
leukotriene metabolic process
lipoxin metabolic process
response to toxic substance
small molecule metabolic process - Gene Ontology Biological Process:
- arachidonic acid metabolic process
cyclooxygenase pathway
leukotriene metabolic process
lipoxin metabolic process
response to toxic substance
small molecule metabolic process - Gene Ontology Molecular Function:
- 13-prostaglandin reductase activity
15-oxoprostaglandin 13-oxidase activity
2-alkenal reductase activity
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
NADP
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome