Names & Taxonomy
- Uniprot ID:
- Q14896
- Entry Name:
- MYPC3_HUMAN
- Status:
- reviewed
- Protein Names:
- Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)
- Gene Names:
- MYBPC3
- Gene Names Primary:
- MYBPC3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1274
- Sequence:
- MPEPGKKPVSAFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPADQGSYAVIAGSSKVKFDLKVIEAEKAEPMLAPAPAPAEATGAPGEAPAPAAELGESAPSPKGSSSAALNGPTPGAPDDPIGLFVMRPQDGEVTVGGSITFSARVAGASLLKPPVVKWFKGKWVDLSSKVGQHLQLHDSYDRASKVYLFELHITDAQPAFTGSYRCEVSTKDKFDCSNFNLTVHEAMGTGDLDLLSAFRRTSLAGGGRRISDSHEDTGILDFSSLLKKRDSFRTPRDSKLEAPAEEDVWEILRQAPPSEYERIAFQYGVTDLRGMLKRLKGMRRDEKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVGGEKCSTELFVKEPPVLITRPLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAELIVQEKKLEVYQSIADLMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSFVPEGFACNLSAKLHFMEVKIDFVPRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPTVIWQKAITQGNKAPARPAPDAPEDTGDSDEWVFDKKLLCETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPKISNVGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMRLNFDLIQELSHEARRMIEGVVYEMRVYAVNAIGMSRPSPASQPFMPIGPPSEPTHLAVEDVSDTTVSLKWRPPERVGAGGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFRVRAHNMAGPGAPVTTTEPVTVQEILQRPRLQLPRHLRQTIQKKVGEPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVSIRNSPTDTILFIRAARRVHSGTYQVTVRIENMEDKATLVLQVVDKPSPPQDLRVTDAWGLNVALEWKPPQDVGNTELWGYTVQKADKKTMEWFTVLEHYRRTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFIPRPGITYEPPNYKALDFSEAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTLEIRKPCPFDGGIYVCRATNLQGEARCECRLEVRVPQ
- Proteomes:
- UP000005640
Function
- Function:
- Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
- Gene Ontology Go:
- A band
C zone
cytosol
sarcomere
striated muscle myosin thick filament
ATPase activator activity
identical protein binding
metal ion binding
myosin binding
myosin heavy chain binding
structural constituent of muscle
titin binding
cardiac muscle contraction
cell adhesion
heart morphogenesis
muscle filament sliding
positive regulation of ATPase activity
regulation of muscle filament sliding
regulation of striated muscle contraction
ventricular cardiac muscle tissue morphogenesis - Gene Ontology Biological Process:
- cardiac muscle contraction
cell adhesion
heart morphogenesis
muscle filament sliding
positive regulation of ATPase activity
regulation of muscle filament sliding
regulation of striated muscle contraction
ventricular cardiac muscle tissue morphogenesis - Gene Ontology Molecular Function:
- ATPase activator activity
identical protein binding
metal ion binding
myosin binding
myosin heavy chain binding
structural constituent of muscle
titin binding - Gene Ontology Cellular Component:
- A band
cytosol
C zone
sarcomere
striated muscle myosin thick filament - Keywords:
- 3D-structure
Acetylation
Actin-binding
Alternative splicing
Cardiomyopathy
Cell adhesion
Complete proteome
Disease mutation
Disulfide bond
Immunoglobulin domain
Metal-binding
Muscle protein
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Thick filament
Ubl conjugation
Zinc - Interacts With:
- Itself; Q5VU43-11
Publication
- PubMed ID:
- 7744002 9048664 9562578 16554811 15489334 7493026 12787675 15213454 18560154 18374358 18926831 9541104 9541115 10521296 11499718 11499719 12379228 11815426 12110947 12951062 12707239 12974739 14563344 12628722 12818575 15114369 15519027 15582318 15563892 16004897 16199542 18957093 18929575 18403758 20215591 21551322 23840593 26163040