Names & Taxonomy
- Uniprot ID:
- Q14832
- Entry Name:
- GRM3_HUMAN
- Status:
- reviewed
- Protein Names:
- Metabotropic glutamate receptor 3 (mGluR3)
- Gene Names:
- GRM3 GPRC1C MGLUR3
- Gene Names Primary:
- GRM3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 879
- Sequence:
- MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
- Gene Ontology Go:
- axon
dendritic spine
integral component of plasma membrane
plasma membrane
postsynaptic density
postsynaptic membrane
presynaptic membrane
calcium channel regulator activity
G-protein coupled receptor activity
glutamate receptor activity
group II metabotropic glutamate receptor activity
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
negative regulation of adenylate cyclase activity
synaptic transmission - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
negative regulation of adenylate cyclase activity
synaptic transmission - Gene Ontology Molecular Function:
- calcium channel regulator activity
glutamate receptor activity
G-protein coupled receptor activity
group II metabotropic glutamate receptor activity - Gene Ontology Cellular Component:
- axon
dendritic spine
integral component of plasma membrane
plasma membrane
postsynaptic density
postsynaptic membrane
presynaptic membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix