Names & Taxonomy
- Uniprot ID:
- Q14728
- Entry Name:
- MFS10_HUMAN
- Status:
- reviewed
- Protein Names:
- Major facilitator superfamily domain-containing protein 10 (Tetracycline transporter-like protein)
- Gene Names:
- MFSD10 TETRAN
- Gene Names Primary:
- MFSD10
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 455
- Sequence:
- MGWGGGGGCTPRPPIHQQPPERRVVTVVFLGLLLDLLAFTLLLPLLPGLLESHGRAHDPLYGSWQGGVDWFATAIGMPVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALGFRDAADLLSPLALLRFSAVARGQDPPSGDRLSSLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMATIQGAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASVYWLAGAQACFTTWSGLFLLPFFLLQKLSYPAQTLKAE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.
- Gene Ontology Go:
- brush border membrane
cytoplasmic vesicle membrane
integral component of membrane
organic anion transmembrane transporter activity
tetracycline transporter activity
apoptotic process
sodium-independent organic anion transport
tetracycline transport
transport - Gene Ontology Biological Process:
- apoptotic process
sodium-independent organic anion transport
tetracycline transport
transport - Gene Ontology Molecular Function:
- organic anion transmembrane transporter activity
tetracycline transporter activity - Gene Ontology Cellular Component:
- brush border membrane
cytoplasmic vesicle membrane
integral component of membrane - Keywords:
- Apoptosis
Complete proteome
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Transport