Names & Taxonomy
- Uniprot ID:
- Q14654
- Entry Name:
- KCJ11_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-sensitive inward rectifier potassium channel 11 (IKATP) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11)
- Gene Names:
- KCNJ11
- Gene Names Primary:
- KCNJ11
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 390
- Sequence:
- MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
- Intramembrane:
- INTRAMEM 117 128 Helical; Pore-forming; Name=H5.
Function
- Function:
- This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
- Cross Reference Drug Bank:
- DB01119 DB00222 DB01016 DB00308 DB00922 DB01154 DB00661 DB01392
- Gene Ontology Go:
- ATP-sensitive potassium channel complex
axolemma
cell body fiber
cytosol
endoplasmic reticulum
endosome
integral component of plasma membrane
intercalated disc
mitochondrion
myelin sheath
neuronal cell body
nuclear envelope
plasma membrane
T-tubule
voltage-gated potassium channel complex
ankyrin binding
ATP binding
ATP-activated inward rectifier potassium channel activity
ion channel binding
potassium ion binding
voltage-gated potassium channel activity
cardiac conduction
cellular response to glucose stimulus
cellular response to nicotine
cellular response to tumor necrosis factor
energy reserve metabolic process
glucose metabolic process
negative regulation of insulin secretion
neurological system process
positive regulation of cation channel activity
potassium ion import
potassium ion transmembrane transport
regulation of cardiac conduction
regulation of insulin secretion
regulation of membrane potential
response to ATP
response to drug
response to estradiol
response to ischemia
response to testosterone
small molecule metabolic process
synaptic transmission
transmembrane transport - Gene Ontology Biological Process:
- cardiac conduction
cellular response to glucose stimulus
cellular response to nicotine
cellular response to tumor necrosis factor
energy reserve metabolic process
glucose metabolic process
negative regulation of insulin secretion
neurological system process
positive regulation of cation channel activity
potassium ion import
potassium ion transmembrane transport
regulation of cardiac conduction
regulation of insulin secretion
regulation of membrane potential
response to ATP
response to drug
response to estradiol
response to ischemia
response to testosterone
small molecule metabolic process
synaptic transmission
transmembrane transport - Gene Ontology Molecular Function:
- ankyrin binding
ATP-activated inward rectifier potassium channel activity
ATP binding
ion channel binding
potassium ion binding
voltage-gated potassium channel activity - Gene Ontology Cellular Component:
- ATP-sensitive potassium channel complex
axolemma
cell body fiber
cytosol
endoplasmic reticulum
endosome
integral component of plasma membrane
intercalated disc
mitochondrion
myelin sheath
neuronal cell body
nuclear envelope
plasma membrane
T-tubule
voltage-gated potassium channel complex - Keywords:
- Alternative splicing
Complete proteome
Diabetes mellitus
Disease mutation
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Potassium
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel
Publication
- PubMed ID:
- 7502040 14702039 16554811 15489334 9831708 12524280 17652641 18596924 19357197 20022885 10338089 17855752 18280666 22701567 7847376 8923010 8897013 9032109 10204114 10391210 12364426 15448106 15448107 15292329 15579781 15115830 15583126 15807877 15718250 15580558 15562009 15784703 15998776 16731833 16609879 16429405 16332676 16357843 17213273