Names & Taxonomy

Uniprot ID:
Q14651
Entry Name:
PLSI_HUMAN
Status:
reviewed
Protein Names:
Plastin-1 (Intestine-specific plastin) (I-plastin)
Gene Names:
PLS1
Gene Names Primary:
PLS1
Organism:
Homo sapiens (Human)

Structure

Length:
629
Sequence:
MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKILSVADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSYSEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGNPKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSISSFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYALPDDLVEVKPKMVMTVFACLMGKGLNRIK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Actin-bundling protein in the absence of calcium.
Gene Ontology Go:
brush border
extracellular exosome
terminal web
actin filament binding
calcium ion binding
structural constituent of cytoskeleton
intestinal D-glucose absorption
positive regulation of establishment of protein localization to plasma membrane
positive regulation of multicellular organism growth
regulation of microvillus length
terminal web assembly
Gene Ontology Biological Process:
intestinal D-glucose absorption
positive regulation of establishment of protein localization to plasma membrane
positive regulation of multicellular organism growth
regulation of microvillus length
terminal web assembly
Gene Ontology Molecular Function:
actin filament binding
calcium ion binding
structural constituent of cytoskeleton
Gene Ontology Cellular Component:
brush border
extracellular exosome
terminal web
Keywords:
Acetylation
Actin-binding
Calcium
Complete proteome
Cytoplasm
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat

Publication

PubMed ID:
8139549 14702039 15489334 21269460 22814378 24275569