Names & Taxonomy

Uniprot ID:
Q14626
Entry Name:
I11RA_HUMAN
Status:
reviewed
Protein Names:
Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA)
Gene Names:
IL11RA
Gene Names Primary:
IL11RA
Organism:
Homo sapiens (Human)

Structure

Length:
422
Sequence:
MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWFRDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHRDSVEQVAVLASLGILSFLGLVAGALALGLWLRLRRGGKDGSPKPGFLASVIPVDRRPGAPNL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.
Cross Reference Drug Bank:
DB00038
Gene Ontology Go:
integral component of plasma membrane
plasma membrane
cytokine receptor activity
signal transducer activity
transmembrane signaling receptor activity
developmental process
embryo implantation
head development
signal transduction
Gene Ontology Biological Process:
developmental process
embryo implantation
head development
signal transduction
Gene Ontology Molecular Function:
cytokine receptor activity
signal transducer activity
transmembrane signaling receptor activity
Gene Ontology Cellular Component:
integral component of plasma membrane
plasma membrane
Keywords:
Alternative splicing
Complete proteome
Craniosynostosis
Disease mutation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
7670098 8808281 15164053 15489334 11141475 21741611