Names & Taxonomy
- Uniprot ID:
- Q14626
- Entry Name:
- I11RA_HUMAN
- Status:
- reviewed
- Protein Names:
- Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA)
- Gene Names:
- IL11RA
- Gene Names Primary:
- IL11RA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 422
- Sequence:
- MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWFRDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHRDSVEQVAVLASLGILSFLGLVAGALALGLWLRLRRGGKDGSPKPGFLASVIPVDRRPGAPNL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.
- Cross Reference Drug Bank:
- DB00038
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
cytokine receptor activity
signal transducer activity
transmembrane signaling receptor activity
developmental process
embryo implantation
head development
signal transduction - Gene Ontology Biological Process:
- developmental process
embryo implantation
head development
signal transduction - Gene Ontology Molecular Function:
- cytokine receptor activity
signal transducer activity
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Craniosynostosis
Disease mutation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix