Names & Taxonomy

Uniprot ID:
Q14576
Entry Name:
ELAV3_HUMAN
Status:
reviewed
Protein Names:
ELAV-like protein 3 (Hu-antigen C) (HuC) (Paraneoplastic cerebellar degeneration-associated antigen) (Paraneoplastic limbic encephalitis antigen 21)
Gene Names:
ELAVL3 HUC PLE21
Gene Names Primary:
ELAVL3
Organism:
Homo sapiens (Human)

Structure

Length:
367
Sequence:
MVTQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA
Proteomes:
UP000005640

Function

Function:
Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance.
Gene Ontology Go:
AU-rich element binding
nucleotide binding
cell differentiation
nervous system development
Gene Ontology Biological Process:
cell differentiation
nervous system development
Gene Ontology Molecular Function:
AU-rich element binding
nucleotide binding
Keywords:
Alternative splicing
Complete proteome
Developmental protein
Differentiation
Neurogenesis
Phosphoprotein
RNA-binding
Reference proteome
Repeat

Publication

PubMed ID:
15057824 15489334 7511893 10710437