Names & Taxonomy
- Uniprot ID:
- Q14573
- Entry Name:
- ITPR3_HUMAN
- Status:
- reviewed
- Protein Names:
- Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)
- Gene Names:
- ITPR3
- Gene Names Primary:
- ITPR3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 2671
- Sequence:
- MSEMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFREKGGEGPLVRLEELSDQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIRTELRPVKEMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRASFCHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFANTMEFVEDYLNNVVSEAVPFANEEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQGPPAMLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDRSKFEENEDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSTTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSGKGEEVEAGAAKDKKERPTDEEGFLHPPGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNMDAHKVMLDLLQIPYDKGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYTSNHIWTLFENFTLDMARVCSKREKRVADPTLEKYVLSVVLDTINAFFSSPFSENSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLPMDLDAHISSMLSSGASCAAAAQRNASSYKATTRAFPRVTPTANQWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDVLHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLMESEEKLCIKVLRTLQQMLLKKTKYGDRGNQLRKMLLQNYLQNRKSTSRGDLPDPIGTGLDPDWSAIAATQCRLDKEGATKLVCDLITSTKNEKIFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRYSLGPSLRRGHEVSERVQSSEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQMLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIAFFYPYMEGASTGVLDSPLISLLFWILICFSIAALFTKRYSIRPLIVALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGLSVPEVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRILQDKLNSTMKLVSHLTAQLNELKEQMTEQRKRRQRLGFVDVQNCISR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
- Cross Reference Drug Bank:
- DB00201
- Gene Ontology Go:
- apical part of cell
brush border
cytoplasm
cytosol
dendrite
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of plasma membrane
membrane
myelin sheath
neuronal cell body
nuclear outer membrane
nucleolus
nucleoplasm
perinuclear region of cytoplasm
plasma membrane
platelet dense tubular network membrane
receptor complex
calcium ion binding
calcium-release channel activity
inositol 1,3,4,5 tetrakisphosphate binding
inositol 1,4,5 trisphosphate binding
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
inositol hexakisphosphate binding
phosphatidylinositol binding
activation of phospholipase C activity
blood coagulation
calcium ion transport into cytosol
cardiac conduction
cellular response to cAMP
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
innate immune response
long-term synaptic potentiation
memory
neurotrophin TRK receptor signaling pathway
platelet activation
positive regulation of cytosolic calcium ion concentration
protein heterooligomerization
protein homooligomerization
regulation of cardiac conduction
regulation of insulin secretion
release of sequestered calcium ion into cytosol
response to calcium ion
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
signal transduction
small molecule metabolic process
stimulatory C-type lectin receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of phospholipase C activity
blood coagulation
calcium ion transport into cytosol
cardiac conduction
cellular response to cAMP
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
innate immune response
long-term synaptic potentiation
memory
neurotrophin TRK receptor signaling pathway
platelet activation
positive regulation of cytosolic calcium ion concentration
protein heterooligomerization
protein homooligomerization
regulation of cardiac conduction
regulation of insulin secretion
release of sequestered calcium ion into cytosol
response to calcium ion
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
signal transduction
small molecule metabolic process
stimulatory C-type lectin receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- calcium ion binding
calcium-release channel activity
inositol 1,3,4,5 tetrakisphosphate binding
inositol 1,4,5 trisphosphate binding
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
inositol hexakisphosphate binding
phosphatidylinositol binding - Gene Ontology Cellular Component:
- apical part of cell
brush border
cytoplasm
cytosol
dendrite
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of plasma membrane
membrane
myelin sheath
neuronal cell body
nuclear outer membrane
nucleolus
nucleoplasm
perinuclear region of cytoplasm
plasma membrane
platelet dense tubular network membrane
receptor complex - Keywords:
- Calcium
Calcium channel
Calcium transport
Complete proteome
Endoplasmic reticulum
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q13507