Names & Taxonomy

Uniprot ID:
Q14573
Entry Name:
ITPR3_HUMAN
Status:
reviewed
Protein Names:
Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)
Gene Names:
ITPR3
Gene Names Primary:
ITPR3
Organism:
Homo sapiens (Human)

Structure

Length:
2671
Sequence:
MSEMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFREKGGEGPLVRLEELSDQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIRTELRPVKEMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRASFCHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFANTMEFVEDYLNNVVSEAVPFANEEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQGPPAMLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDRSKFEENEDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSTTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSGKGEEVEAGAAKDKKERPTDEEGFLHPPGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNMDAHKVMLDLLQIPYDKGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYTSNHIWTLFENFTLDMARVCSKREKRVADPTLEKYVLSVVLDTINAFFSSPFSENSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLPMDLDAHISSMLSSGASCAAAAQRNASSYKATTRAFPRVTPTANQWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDVLHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLMESEEKLCIKVLRTLQQMLLKKTKYGDRGNQLRKMLLQNYLQNRKSTSRGDLPDPIGTGLDPDWSAIAATQCRLDKEGATKLVCDLITSTKNEKIFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRYSLGPSLRRGHEVSERVQSSEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQMLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIAFFYPYMEGASTGVLDSPLISLLFWILICFSIAALFTKRYSIRPLIVALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGLSVPEVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRILQDKLNSTMKLVSHLTAQLNELKEQMTEQRKRRQRLGFVDVQNCISR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein.

Function

Function:
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
Cross Reference Drug Bank:
DB00201
Gene Ontology Go:
apical part of cell
brush border
cytoplasm
cytosol
dendrite
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of plasma membrane
membrane
myelin sheath
neuronal cell body
nuclear outer membrane
nucleolus
nucleoplasm
perinuclear region of cytoplasm
plasma membrane
platelet dense tubular network membrane
receptor complex
calcium ion binding
calcium-release channel activity
inositol 1,3,4,5 tetrakisphosphate binding
inositol 1,4,5 trisphosphate binding
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
inositol hexakisphosphate binding
phosphatidylinositol binding
activation of phospholipase C activity
blood coagulation
calcium ion transport into cytosol
cardiac conduction
cellular response to cAMP
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
innate immune response
long-term synaptic potentiation
memory
neurotrophin TRK receptor signaling pathway
platelet activation
positive regulation of cytosolic calcium ion concentration
protein heterooligomerization
protein homooligomerization
regulation of cardiac conduction
regulation of insulin secretion
release of sequestered calcium ion into cytosol
response to calcium ion
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
signal transduction
small molecule metabolic process
stimulatory C-type lectin receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Biological Process:
activation of phospholipase C activity
blood coagulation
calcium ion transport into cytosol
cardiac conduction
cellular response to cAMP
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
innate immune response
long-term synaptic potentiation
memory
neurotrophin TRK receptor signaling pathway
platelet activation
positive regulation of cytosolic calcium ion concentration
protein heterooligomerization
protein homooligomerization
regulation of cardiac conduction
regulation of insulin secretion
release of sequestered calcium ion into cytosol
response to calcium ion
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
signal transduction
small molecule metabolic process
stimulatory C-type lectin receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Molecular Function:
calcium ion binding
calcium-release channel activity
inositol 1,3,4,5 tetrakisphosphate binding
inositol 1,4,5 trisphosphate binding
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
inositol hexakisphosphate binding
phosphatidylinositol binding
Gene Ontology Cellular Component:
apical part of cell
brush border
cytoplasm
cytosol
dendrite
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of plasma membrane
membrane
myelin sheath
neuronal cell body
nuclear outer membrane
nucleolus
nucleoplasm
perinuclear region of cytoplasm
plasma membrane
platelet dense tubular network membrane
receptor complex
Keywords:
Calcium
Calcium channel
Calcium transport
Complete proteome
Endoplasmic reticulum
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q13507

Publication

PubMed ID:
8081734 8288584 14574404 12032348 18826956 18669648 19553469 19690332 20068231 21269460 23936024 24275569 25996873