Names & Taxonomy
- Uniprot ID:
- Q14542
- Entry Name:
- S29A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Equilibrative nucleoside transporter 2 (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2)
- Gene Names:
- SLC29A2 DER12 ENT2 HNP36
- Gene Names Primary:
- SLC29A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 456
- Sequence:
- MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTGPEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVDMSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAELLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLVFTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRLLPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Basolateral cell membrane
Function
- Function:
- Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: ; Kinetic parameters: KM=0.2 mM for uridine
- Cross Reference Drug Bank:
- DB00900 DB00898 DB00441 DB01033 DB00943 DB00495
- Gene Ontology Go:
- basolateral plasma membrane
integral component of plasma membrane
nuclear membrane
nucleolus
plasma membrane
nucleoside transmembrane transporter activity
cell proliferation
nucleobase-containing compound metabolic process
nucleoside transport
transmembrane transport - Gene Ontology Biological Process:
- cell proliferation
nucleobase-containing compound metabolic process
nucleoside transport
transmembrane transport - Gene Ontology Molecular Function:
- nucleoside transmembrane transporter activity
- Gene Ontology Cellular Component:
- basolateral plasma membrane
integral component of plasma membrane
nuclear membrane
nucleolus
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Membrane
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport