Names & Taxonomy

Uniprot ID:
Q14542
Entry Name:
S29A2_HUMAN
Status:
reviewed
Protein Names:
Equilibrative nucleoside transporter 2 (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2)
Gene Names:
SLC29A2 DER12 ENT2 HNP36
Gene Names Primary:
SLC29A2
Organism:
Homo sapiens (Human)

Structure

Length:
456
Sequence:
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTGPEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVDMSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAELLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLVFTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRLLPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Basolateral cell membrane

Function

Function:
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: ; Kinetic parameters: KM=0.2 mM for uridine
Cross Reference Drug Bank:
DB00900 DB00898 DB00441 DB01033 DB00943 DB00495
Gene Ontology Go:
basolateral plasma membrane
integral component of plasma membrane
nuclear membrane
nucleolus
plasma membrane
nucleoside transmembrane transporter activity
cell proliferation
nucleobase-containing compound metabolic process
nucleoside transport
transmembrane transport
Gene Ontology Biological Process:
cell proliferation
nucleobase-containing compound metabolic process
nucleoside transport
transmembrane transport
Gene Ontology Molecular Function:
nucleoside transmembrane transporter activity
Gene Ontology Cellular Component:
basolateral plasma membrane
integral component of plasma membrane
nuclear membrane
nucleolus
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Membrane
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
7639753 9396714 9478986 12527552 14702039 16554811 15489334 12590919 19413330 20068231 21406692 16214850