Names & Taxonomy
- Uniprot ID:
- Q14534
- Entry Name:
- ERG1_HUMAN
- Status:
- reviewed
- Protein Names:
- Squalene monooxygenase (EC 1.14.14.17) (Squalene epoxidase) (SE)
- Gene Names:
- SQLE ERG1
- Gene Names Primary:
- SQLE
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 574
- Sequence:
- MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQQSGSQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Function
- Function:
- Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
- Pathway:
- Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.
- Catalytic Activity:
- Squalene + + O(2) = (3S)-2,3-epoxy-2,3-dihydrosqualene + + H(2)O.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Cross Reference Drug Bank:
- DB01091 DB00735 DB00857
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
flavin adenine dinucleotide binding
squalene monooxygenase activity
cellular aromatic compound metabolic process
cholesterol biosynthetic process
response to organic substance
small molecule metabolic process
sterol biosynthetic process - Gene Ontology Biological Process:
- cellular aromatic compound metabolic process
cholesterol biosynthetic process
response to organic substance
small molecule metabolic process
sterol biosynthetic process - Gene Ontology Molecular Function:
- flavin adenine dinucleotide binding
squalene monooxygenase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Complete proteome
Endoplasmic reticulum
FAD
Flavoprotein
Membrane
Microsome
NADP
Oxidoreductase
Reference proteome
Transmembrane
Transmembrane helix