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Names & Taxonomy

Uniprot ID:: Q14524
Entry Name:: SCN5A_HUMAN
Status:: reviewed
Protein Names:: Sodium channel protein type 5 subunit alpha (HH1) (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5)
Gene Names:: SCN5A
Gene Names Primary:: SCN5A
Organism:: Homo sapiens (Human)

Structure

Length:: 2016
Sequence:: MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Membrane

Function

Function:: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.
Cross Reference Drug Bank:: DB01426 DB01429 DB00868 DB00564 DB00527 DB00907 DB00280 DB01228 DB00754 DB01195 DB01320 DB00473 DB00192 DB00281 DB00379 DB00680 DB00776 DB00252 DB00750 DB01035 DB01182 DB00908 DB01346 DB00243 DB00740 DB01056 DB00313 DB00661 DB00909
Gene Ontology Go:: caveola
cell surface
endoplasmic reticulum
integral component of membrane
intercalated disc
intracellular
lateral plasma membrane
plasma membrane
sarcolemma
T-tubule
voltage-gated sodium channel complex
Z disc
ankyrin binding
calmodulin binding
enzyme binding
fibroblast growth factor binding
ion channel binding
nitric-oxide synthase binding
protein domain specific binding
protein kinase binding
scaffold protein binding
ubiquitin protein ligase binding
voltage-gated sodium channel activity
voltage-gated sodium channel activity involved in AV node cell action potential
voltage-gated sodium channel activity involved in bundle of His cell action potential
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
voltage-gated sodium channel activity involved in Purkinje myocyte action potential
voltage-gated sodium channel activity involved in SA node cell action potential
AV node cell action potential
AV node cell to bundle of His cell communication
axon guidance
brainstem development
bundle of His cell action potential
cardiac conduction
cardiac muscle cell action potential involved in contraction
cardiac muscle contraction
cardiac ventricle development
cellular response to calcium ion
cerebellum development
membrane depolarization
membrane depolarization during action potential
membrane depolarization during AV node cell action potential
membrane depolarization during bundle of His cell action potential
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during Purkinje myocyte cell action potential
membrane depolarization during SA node cell action potential
neuronal action potential
odontogenesis of dentin-containing tooth
positive regulation of action potential
positive regulation of epithelial cell proliferation
positive regulation of sodium ion transport
regulation of atrial cardiac muscle cell membrane depolarization
regulation of atrial cardiac muscle cell membrane repolarization
regulation of cardiac muscle cell contraction
regulation of heart rate
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transport
regulation of ventricular cardiac muscle cell membrane depolarization
regulation of ventricular cardiac muscle cell membrane repolarization
response to denervation involved in regulation of muscle adaptation
SA node cell action potential
sodium ion transmembrane transport
sodium ion transport
telencephalon development
ventricular cardiac muscle cell action potential
Gene Ontology Biological Process:: AV node cell action potential
AV node cell to bundle of His cell communication
axon guidance
brainstem development
bundle of His cell action potential
cardiac conduction
cardiac muscle cell action potential involved in contraction
cardiac muscle contraction
cardiac ventricle development
cellular response to calcium ion
cerebellum development
membrane depolarization
membrane depolarization during action potential
membrane depolarization during AV node cell action potential
membrane depolarization during bundle of His cell action potential
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during Purkinje myocyte cell action potential
membrane depolarization during SA node cell action potential
neuronal action potential
odontogenesis of dentin-containing tooth
positive regulation of action potential
positive regulation of epithelial cell proliferation
positive regulation of sodium ion transport
regulation of atrial cardiac muscle cell membrane depolarization
regulation of atrial cardiac muscle cell membrane repolarization
regulation of cardiac muscle cell contraction
regulation of heart rate
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transport
regulation of ventricular cardiac muscle cell membrane depolarization
regulation of ventricular cardiac muscle cell membrane repolarization
response to denervation involved in regulation of muscle adaptation
SA node cell action potential
sodium ion transmembrane transport
sodium ion transport
telencephalon development
ventricular cardiac muscle cell action potential
Gene Ontology Molecular Function:: ankyrin binding
calmodulin binding
enzyme binding
fibroblast growth factor binding
ion channel binding
nitric-oxide synthase binding
protein domain specific binding
protein kinase binding
scaffold protein binding
ubiquitin protein ligase binding
voltage-gated sodium channel activity
voltage-gated sodium channel activity involved in AV node cell action potential
voltage-gated sodium channel activity involved in bundle of His cell action potential
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
voltage-gated sodium channel activity involved in Purkinje myocyte action potential
voltage-gated sodium channel activity involved in SA node cell action potential
Gene Ontology Cellular Component:: caveola
cell surface
endoplasmic reticulum
integral component of membrane
intercalated disc
intracellular
lateral plasma membrane
plasma membrane
sarcolemma
T-tubule
voltage-gated sodium channel complex
Z disc
Keywords:: 3D-structure
Alternative splicing
Atrial fibrillation
Brugada syndrome
Calmodulin-binding
Cardiomyopathy
Complete proteome
Disease mutation
Glycoprotein
Ion channel
Ion transport
Long QT syndrome
Membrane
Methylation
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Sodium
Sodium channel
Sodium transport
Transmembrane
Transmembrane helix
Transport
Ubl conjugation
Voltage-gated channel
Interacts With:: P62158; Q13557; Q99873; O60678; P26045

Publication

PubMed ID:: 1309946 12358675 14500339 12454206 16115203 16641997 15489334 15217910 15548568 16054936 19666841 19376164 19027780 20398673 21817159 21726068 23092124 24898004 19074138 21167176 22705208 7889574 8541846 7651517 9686753 9506831 10627139 9521325 10508990 10690282 10377081 10532948 10590249 10471492 10618304 10973849 10940383 10911008 11304498 11410597 11748104 11710892 11234013 12106943 11804990 11889015 11901046 11997281 11823453 12471205 12051963 12209021 12193783 12522116 12574143 12673799 12569159 14523039 15023552 15466643 15338453 15579534 16266370 15851320 16414944 15840476 16325048 16616735 17075016 16922724 17081365 18708744 17198989 18060054 18341814 18616619 18456723 18252757 18599870 18378609 18088563 18929331 18848812 18929244 18451998 18368697 18596570 19056759 19302788 19251209 19716085 19272188 20129283 21109022 22795782