Names & Taxonomy
- Uniprot ID:
- Q14520
- Entry Name:
- HABP2_HUMAN
- Status:
- reviewed
- Protein Names:
- Hyaluronan-binding protein 2 (EC 3.4.21.-) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) (Hepatocyte growth factor activator-like protein) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]
- Gene Names:
- HABP2 HGFAL PHBP
- Gene Names Primary:
- HABP2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 560
- Sequence:
- MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLTHAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPCGRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTAAHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVYTQVTKFLNWIKATIKSESGF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (PubMed:8827452, PubMed:10754382, PubMed:11217080). May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560).
- Active Site:
- ACT_SITE 362 362 Charge relay system.
- Cross Reference Drug Bank:
- DB08818
- Gene Ontology Go:
- extracellular region
extracellular space
glycosaminoglycan binding
serine-type endopeptidase activity
cell adhesion - Gene Ontology Biological Process:
- cell adhesion
- Gene Ontology Molecular Function:
- glycosaminoglycan binding
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- extracellular region
extracellular space - Keywords:
- Alternative splicing
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Hydrolase
Kringle
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal