Names & Taxonomy

Uniprot ID:
Q14494
Entry Name:
NF2L1_HUMAN
Status:
reviewed
Protein Names:
Nuclear factor erythroid 2-related factor 1 (NF-E2-related factor 1) (NFE2-related factor 1) (Locus control region-factor 1) (Nuclear factor, erythroid derived 2, like 1) (Transcription factor 11) (TCF-11) (Transcription factor HBZ17) (Transcription factor LCR-F1)
Gene Names:
NFE2L1 HBZ17 NRF1 TCF11
Gene Names Primary:
NFE2L1
Organism:
Homo sapiens (Human)

Structure

Length:
772
Sequence:
MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQLPPLREIILGPSSAYTQTQFHNLRNTLDGYGIHPKSIDLDNYFTARRLLSQVRALDRFQVPTTEVNAWLVHRDPEGSVSGSQPNSGLALESSSGLQDVTGPDNGVRESETEQGFGEDLEDLGAVAPPVSGDLTKEDIDLIDILWRQDIDLGAGREVFDYSHRQKEQDVEKELRDGGEQDTWAGEGAEALARNLLVDGETGESFPAQVPSGEDQTALSLEECLRLLEATCPFGENAEFPADISSITEAVPSESEPPALQNNLLSPLLTGTESPFDLEQQWQDLMSIMEMQAMEVNTSASEILYSAPPGDPLSTNYSLAPNTPINQNVSLHQASLGGCSQDFLLFSPEVESLPVASSSTLLPLAPSNSTSLNSTFGSTNLTGLFFPPQLNGTANDTAGPELPDPLGGLLDEAMLDEISLMDLAIEEGFNPVQASQLEEEFDSDSGLSLDSSHSPSSLSSSEGSSSSSSSSSSSSSSASSSASSSFSEEGAVGYSSDSETLDLEEAEGAVGYQPEYSKFCRMSYQDPAQLSCLPYLEHVGHNHTYNMAPSALDSADLPPPSALKKGSKEKQADFLDKQMSRDEHRARAMKIPFTNDKIINLPVEEFNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKVEFLRSLRQMKQKVQSLYQEVFGRLRDENGRPYSPSQYALQYAGDGSVLLIPRTMADQQARRQERKPKDRRK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Activates erythroid-specific, globin gene expression.
Gene Ontology Go:
cytoplasm
endoplasmic reticulum membrane
integral component of membrane
nucleus
RNA polymerase II distal enhancer sequence-specific DNA binding
transcription cofactor activity
transcription factor activity, sequence-specific DNA binding
transcription regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription factor binding
anatomical structure morphogenesis
cellular response to oxidative stress
erythrocyte differentiation
heme biosynthetic process
inflammatory response
positive regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
Gene Ontology Biological Process:
anatomical structure morphogenesis
cellular response to oxidative stress
erythrocyte differentiation
heme biosynthetic process
inflammatory response
positive regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
Gene Ontology Molecular Function:
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription factor binding
transcription cofactor activity
transcription factor activity, sequence-specific DNA binding
transcription regulatory region sequence-specific DNA binding
Gene Ontology Cellular Component:
cytoplasm
endoplasmic reticulum membrane
integral component of membrane
nucleus
Keywords:
Activator
Alternative splicing
Complete proteome
DNA-binding
Endoplasmic reticulum
Membrane
Nucleus
Polymorphism
Reference proteome
Signal-anchor
Transcription
Transcription regulation
Transmembrane
Transmembrane helix
Interacts With:
Q9NS37; O15525

Publication

PubMed ID:
8248256 8001966 15489334 8036168 16687406