Names & Taxonomy
- Uniprot ID:
- Q14353
- Entry Name:
- GAMT_HUMAN
- Status:
- reviewed
- Protein Names:
- Guanidinoacetate N-methyltransferase (EC 2.1.1.2)
- Gene Names:
- GAMT
- Gene Names Primary:
- GAMT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 236
- Sequence:
- MSAPSATPIFAPGENCSPAWGAAPAAYDAADTHLRILGKPVMERWETPYMHALAAAASSKGGRVLEVGFGMAIAASKVQEAPIDEHWIIECNDGVFQRLRDWAPRQTHKVIPLKGLWEDVAPTLPDGHFDGILYDTYPLSEETWHTHQFNFIKNHAFRLLKPGGVLTYCNLTSWGELMKSKYSDITIMFEETQVPALLEAGFRRENIRTEVMALVPPADCRYYAFPQMITPLVTKG
- Proteomes:
- UP000005640
Function
- Function:
- Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor (PubMed:26003046, PubMed:24415674, PubMed:26319512). Important in nervous system development (PubMed:24415674).
- Pathway:
- Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 2/2.
- Catalytic Activity:
- S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine.
- Cross Reference Drug Bank:
- DB00148 DB00536
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleus
guanidinoacetate N-methyltransferase activity
methyltransferase activity
cellular nitrogen compound metabolic process
creatine biosynthetic process
creatine metabolic process
embryonic liver development
muscle contraction
organ morphogenesis
polyamine metabolic process
regulation of multicellular organism growth
S-adenosylhomocysteine metabolic process
S-adenosylmethionine metabolic process
small molecule metabolic process
spermatogenesis - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
creatine biosynthetic process
creatine metabolic process
embryonic liver development
muscle contraction
organ morphogenesis
polyamine metabolic process
regulation of multicellular organism growth
S-adenosylhomocysteine metabolic process
S-adenosylmethionine metabolic process
small molecule metabolic process
spermatogenesis - Gene Ontology Molecular Function:
- guanidinoacetate N-methyltransferase activity
methyltransferase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Methyltransferase
Polymorphism
Reference proteome
S-adenosyl-L-methionine
Transferase