Names & Taxonomy
- Uniprot ID:
- Q14162
- Entry Name:
- SREC_HUMAN
- Status:
- reviewed
- Protein Names:
- Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I)
- Gene Names:
- SCARF1 KIAA0149 SREC
- Gene Names Primary:
- SCARF1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 830
- Sequence:
- MGLGLLLPLLLLWTRGTQGSELDPKGQHVCVASSPSAELQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRCSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRDTALIAGSLVPLLLLFLGLACCACCCWAPRSDLKDRPARDGATVSRMKLQVWGTLTSLGSTLPCRSLSSHKLPWVTVSHHDPEVPFNHSFIEPPSAGWATDDSFSSDPESGEADEVPAYCVPPQEGMVPVAQAGSSEASLAAGAFPPPEDASTPFAIPRTSSLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQSGPEGREAEESTGPEEAEAPESFPAAASPGDSATGHRRPPLGGRTVAEHVEAIEGSVQESSGPVTTIYMLAGKPRGSEGPVRSVFRHFGSFQKGQAEAKVKRAIPKPPRQALNRKKGSPGLASGSVGQSPNSAPKAGLPGATGPMAVRPEEAVRGLGAGTESSRRAQEPVSGCGSPEQDPQKQAEEERQEEPEYENVVPISRPPEP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).
- Gene Ontology Go:
- endocytic vesicle membrane
integral component of membrane
plasma membrane
low-density lipoprotein particle binding
scavenger receptor activity
transmembrane signaling receptor activity
cell adhesion
cholesterol catabolic process
dendrite development
neuron remodeling
positive regulation of axon regeneration
positive regulation of neuron projection development
receptor-mediated endocytosis
signal transduction - Gene Ontology Biological Process:
- cell adhesion
cholesterol catabolic process
dendrite development
neuron remodeling
positive regulation of axon regeneration
positive regulation of neuron projection development
receptor-mediated endocytosis
signal transduction - Gene Ontology Molecular Function:
- low-density lipoprotein particle binding
scavenger receptor activity
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- endocytic vesicle membrane
integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Cell adhesion
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix