Names & Taxonomy

Uniprot ID:
Q14003
Entry Name:
KCNC3_HUMAN
Status:
reviewed
Protein Names:
Potassium voltage-gated channel subfamily C member 3 (KSHIIID) (Voltage-gated potassium channel subunit Kv3.3)
Gene Names:
KCNC3
Gene Names Primary:
KCNC3
Organism:
Homo sapiens (Human)

Structure

Length:
757
Sequence:
MLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRGPGDRRAEPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVAGAYPAGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIEINRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACFLLTDYAPSPDGSIRKATGAPPLPPQDWRKPGPPSFLPDLNANAAAWISP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Cross Reference Drug Bank:
DB06637
Gene Ontology Go:
plasma membrane
voltage-gated potassium channel complex
delayed rectifier potassium channel activity
voltage-gated potassium channel activity
potassium ion transmembrane transport
protein homooligomerization
protein tetramerization
synaptic transmission
Gene Ontology Biological Process:
potassium ion transmembrane transport
protein homooligomerization
protein tetramerization
synaptic transmission
Gene Ontology Molecular Function:
delayed rectifier potassium channel activity
voltage-gated potassium channel activity
Gene Ontology Cellular Component:
plasma membrane
voltage-gated potassium channel complex
Keywords:
Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Ion channel
Ion transport
Membrane
Neurodegeneration
Phosphoprotein
Potassium
Potassium channel
Potassium transport
Reference proteome
Spinocerebellar ataxia
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel

Publication

PubMed ID:
10712820 15057824 23734863 25152487 16501573 19953606 21479265 25756792