Names & Taxonomy

Uniprot ID:
Q13621
Entry Name:
S12A1_HUMAN
Status:
reviewed
Protein Names:
Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (Kidney-specific Na-K-Cl symporter)
Gene Names:
SLC12A1 NKCC2
Gene Names Primary:
SLC12A1
Organism:
Homo sapiens (Human)

Structure

Length:
1099
Sequence:
MSLNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPHYEETSFGDEAQKRLRISFRPGNQECYDNFLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
Enzyme Regulation:
ENZYME REGULATION: Activated by WNK3.
Cross Reference Drug Bank:
DB00887 DB00534 DB00310 DB00903 DB00695 DB00774 DB00232 DB00761 DB01325 DB00214 DB01021
Gene Ontology Go:
apical plasma membrane
cell surface
extracellular exosome
integral component of membrane
membrane
plasma membrane
sodium:potassium:chloride symporter activity
diterpenoid metabolic process
ion transmembrane transport
ion transport
potassium ion transport
protein insertion into membrane from inner side
sodium ion transport
transmembrane transport
transport
Gene Ontology Biological Process:
diterpenoid metabolic process
ion transmembrane transport
ion transport
potassium ion transport
protein insertion into membrane from inner side
sodium ion transport
transmembrane transport
transport
Gene Ontology Molecular Function:
sodium:potassium:chloride symporter activity
Gene Ontology Cellular Component:
apical plasma membrane
cell surface
extracellular exosome
integral component of membrane
membrane
plasma membrane
Keywords:
Alternative splicing
Bartter syndrome
Complete proteome
Disease mutation
Glycoprotein
Ion transport
Membrane
Neurodegeneration
Phosphoprotein
Potassium
Potassium transport
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
8640224 16572171 21613606