Names & Taxonomy
- Uniprot ID:
- Q13621
- Entry Name:
- S12A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (Kidney-specific Na-K-Cl symporter)
- Gene Names:
- SLC12A1 NKCC2
- Gene Names Primary:
- SLC12A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1099
- Sequence:
- MSLNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPHYEETSFGDEAQKRLRISFRPGNQECYDNFLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
- Enzyme Regulation:
- ENZYME REGULATION: Activated by WNK3.
- Cross Reference Drug Bank:
- DB00887 DB00534 DB00310 DB00903 DB00695 DB00774 DB00232 DB00761 DB01325 DB00214 DB01021
- Gene Ontology Go:
- apical plasma membrane
cell surface
extracellular exosome
integral component of membrane
membrane
plasma membrane
sodium:potassium:chloride symporter activity
diterpenoid metabolic process
ion transmembrane transport
ion transport
potassium ion transport
protein insertion into membrane from inner side
sodium ion transport
transmembrane transport
transport - Gene Ontology Biological Process:
- diterpenoid metabolic process
ion transmembrane transport
ion transport
potassium ion transport
protein insertion into membrane from inner side
sodium ion transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- sodium:potassium:chloride symporter activity
- Gene Ontology Cellular Component:
- apical plasma membrane
cell surface
extracellular exosome
integral component of membrane
membrane
plasma membrane - Keywords:
- Alternative splicing
Bartter syndrome
Complete proteome
Disease mutation
Glycoprotein
Ion transport
Membrane
Neurodegeneration
Phosphoprotein
Potassium
Potassium transport
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport