Names & Taxonomy

Uniprot ID:
Q13555
Entry Name:
KCC2G_HUMAN
Status:
reviewed
Protein Names:
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17)
Gene Names:
CAMK2G CAMK CAMK-II CAMKG
Gene Names Primary:
CAMK2G
Organism:
Homo sapiens (Human)

Structure

Length:
558
Sequence:
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKARSPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Sarcoplasmic reticulum membrane

Function

Function:
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
Catalytic Activity:
ATP + a protein = ADP + a phosphoprotein.
Enzyme Regulation:
ENZYME REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
Active Site:
ACT_SITE 136 136 Proton acceptor.
Cross Reference Drug Bank:
DB06616
Gene Ontology Go:
cytosol
endocytic vesicle membrane
membrane
neuronal postsynaptic density
nucleoplasm
plasma membrane
sarcoplasmic reticulum membrane
ATP binding
calcium-dependent protein serine/threonine phosphatase activity
calmodulin binding
calmodulin-dependent protein kinase activity
protein homodimerization activity
activation of MAPKK activity
axon guidance
calcium ion transport
cellular response to heat
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G1/S transition of mitotic cell cycle
innate immune response
insulin receptor signaling pathway
insulin secretion
interferon-gamma-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
protein autophosphorylation
protein dephosphorylation
protein oligomerization
Ras protein signal transduction
regulation of calcium ion transport
regulation of cellular response to heat
regulation of relaxation of cardiac muscle
regulation of skeletal muscle adaptation
small GTPase mediated signal transduction
synaptic transmission
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Biological Process:
activation of MAPKK activity
axon guidance
calcium ion transport
cellular response to heat
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G1/S transition of mitotic cell cycle
innate immune response
insulin receptor signaling pathway
insulin secretion
interferon-gamma-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
protein autophosphorylation
protein dephosphorylation
protein oligomerization
Ras protein signal transduction
regulation of calcium ion transport
regulation of cellular response to heat
regulation of relaxation of cardiac muscle
regulation of skeletal muscle adaptation
small GTPase mediated signal transduction
synaptic transmission
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Molecular Function:
ATP binding
calcium-dependent protein serine/threonine phosphatase activity
calmodulin binding
calmodulin-dependent protein kinase activity
protein homodimerization activity
Gene Ontology Cellular Component:
cytosol
endocytic vesicle membrane
membrane
neuronal postsynaptic density
nucleoplasm
plasma membrane
sarcoplasmic reticulum membrane
Keywords:
3D-structure
ATP-binding
Alternative splicing
Calmodulin-binding
Complete proteome
Developmental protein
Differentiation
Kinase
Membrane
Neurogenesis
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Sarcoplasmic reticulum
Serine/threonine-protein kinase
Transferase
Interacts With:
P08238

Publication

PubMed ID:
15164054 15489334 9240463 12032636 8449910 9060999 7557101 14722083 16690701 15294044 18691976 18669648 19369195 20068231 21269460 24275569 20668654 23033978