Names & Taxonomy
- Uniprot ID:
- Q13555
- Entry Name:
- KCC2G_HUMAN
- Status:
- reviewed
- Protein Names:
- Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17)
- Gene Names:
- CAMK2G CAMK CAMK-II CAMKG
- Gene Names Primary:
- CAMK2G
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 558
- Sequence:
- MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKARSPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Sarcoplasmic reticulum membrane
Function
- Function:
- Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Enzyme Regulation:
- ENZYME REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
- Active Site:
- ACT_SITE 136 136 Proton acceptor.
- Cross Reference Drug Bank:
- DB06616
- Gene Ontology Go:
- cytosol
endocytic vesicle membrane
membrane
neuronal postsynaptic density
nucleoplasm
plasma membrane
sarcoplasmic reticulum membrane
ATP binding
calcium-dependent protein serine/threonine phosphatase activity
calmodulin binding
calmodulin-dependent protein kinase activity
protein homodimerization activity
activation of MAPKK activity
axon guidance
calcium ion transport
cellular response to heat
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G1/S transition of mitotic cell cycle
innate immune response
insulin receptor signaling pathway
insulin secretion
interferon-gamma-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
protein autophosphorylation
protein dephosphorylation
protein oligomerization
Ras protein signal transduction
regulation of calcium ion transport
regulation of cellular response to heat
regulation of relaxation of cardiac muscle
regulation of skeletal muscle adaptation
small GTPase mediated signal transduction
synaptic transmission
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
calcium ion transport
cellular response to heat
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G1/S transition of mitotic cell cycle
innate immune response
insulin receptor signaling pathway
insulin secretion
interferon-gamma-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
protein autophosphorylation
protein dephosphorylation
protein oligomerization
Ras protein signal transduction
regulation of calcium ion transport
regulation of cellular response to heat
regulation of relaxation of cardiac muscle
regulation of skeletal muscle adaptation
small GTPase mediated signal transduction
synaptic transmission
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- ATP binding
calcium-dependent protein serine/threonine phosphatase activity
calmodulin binding
calmodulin-dependent protein kinase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytosol
endocytic vesicle membrane
membrane
neuronal postsynaptic density
nucleoplasm
plasma membrane
sarcoplasmic reticulum membrane - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Calmodulin-binding
Complete proteome
Developmental protein
Differentiation
Kinase
Membrane
Neurogenesis
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Sarcoplasmic reticulum
Serine/threonine-protein kinase
Transferase - Interacts With:
- P08238