Names & Taxonomy

Uniprot ID:
Q13554
Entry Name:
KCC2B_HUMAN
Status:
reviewed
Protein Names:
Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
Gene Names:
CAMK2B CAM2 CAMK2 CAMKB
Gene Names Primary:
CAMK2B
Organism:
Homo sapiens (Human)

Structure

Length:
666
Sequence:
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVRRGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytoskeleton

Function

Function:
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
Catalytic Activity:
ATP + a protein = ADP + a phosphoprotein.
Enzyme Regulation:
ENZYME REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
Active Site:
ACT_SITE 136 136 Proton acceptor.
Gene Ontology Go:
cytosol
dendrite
endocytic vesicle membrane
microtubule organizing center
nucleoplasm
perikaryon
plasma membrane
postsynaptic density
sarcoplasmic reticulum membrane
ATP binding
calmodulin-dependent protein kinase activity
protein homodimerization activity
activation of MAPKK activity
axon guidance
cellular response to heat
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
interferon-gamma-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
positive regulation of dendritic spine morphogenesis
positive regulation of neuron projection development
positive regulation of phospholipase A2 activity
positive regulation of synapse maturation
protein autophosphorylation
protein phosphorylation
Ras protein signal transduction
regulation of calcium ion transport
regulation of cellular response to heat
regulation of dendritic spine development
regulation of long-term neuronal synaptic plasticity
regulation of skeletal muscle adaptation
regulation of synapse structural plasticity
signal transduction
small GTPase mediated signal transduction
synaptic transmission
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Biological Process:
activation of MAPKK activity
axon guidance
cellular response to heat
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
interferon-gamma-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
positive regulation of dendritic spine morphogenesis
positive regulation of neuron projection development
positive regulation of phospholipase A2 activity
positive regulation of synapse maturation
protein autophosphorylation
protein phosphorylation
Ras protein signal transduction
regulation of calcium ion transport
regulation of cellular response to heat
regulation of dendritic spine development
regulation of long-term neuronal synaptic plasticity
regulation of skeletal muscle adaptation
regulation of synapse structural plasticity
signal transduction
small GTPase mediated signal transduction
synaptic transmission
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Molecular Function:
ATP binding
calmodulin-dependent protein kinase activity
protein homodimerization activity
Gene Ontology Cellular Component:
cytosol
dendrite
endocytic vesicle membrane
microtubule organizing center
nucleoplasm
perikaryon
plasma membrane
postsynaptic density
sarcoplasmic reticulum membrane
Keywords:
3D-structure
ATP-binding
Actin-binding
Alternative splicing
Calmodulin-binding
Complete proteome
Cytoplasm
Cytoskeleton
Developmental protein
Differentiation
Kinase
Membrane
Neurogenesis
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Sarcoplasmic reticulum
Serine/threonine-protein kinase
Transferase
Interacts With:
B3KWQ7; O00154; Q2VPB7; Q8N0U1; P60412; Q3LI72; Q3SYF9; Q9UI95; Q9BUE0; Q9UBU8; Q9UBU8-2; Q9Y3B7; Q93100; Q969H6; P61225; O43251; Q93062; P62913; Q9NTN9-3; Q5W111; Q8N0Z6

Publication

PubMed ID:
10858498 10819240 14702039 12690205 15489334 9060999 14722083 15312654 16690701 19369195 21529938 15294044 18817731 19996366 24275569 17344846