Names & Taxonomy

Uniprot ID:
Q13547
Entry Name:
HDAC1_HUMAN
Status:
reviewed
Protein Names:
Histone deacetylase 1 (HD1) (EC 3.5.1.98)
Gene Names:
HDAC1 RPD3L1
Gene Names Primary:
HDAC1
Organism:
Homo sapiens (Human)

Structure

Length:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
Catalytic Activity:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Active Site:
ACT_SITE 141 141
Cross Reference Drug Bank:
DB06603 DB02546
Gene Ontology Go:
chromatin
cytoplasm
cytosol
histone deacetylase complex
nuclear chromatin
nucleoplasm
nucleus
NuRD complex
protein complex
Sin3 complex
activating transcription factor binding
core promoter binding
deacetylase activity
enzyme binding
histone deacetylase activity
histone deacetylase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
NF-kappaB binding
protein deacetylase activity
protein N-terminus binding
repressing transcription factor binding
RNA polymerase II repressing transcription factor binding
RNA polymerase II transcription corepressor activity
RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcription regulatory region DNA binding
transcription regulatory region sequence-specific DNA binding
ATP-dependent chromatin remodeling
blood coagulation
chromatin modification
chromatin organization
chromatin remodeling
circadian regulation of gene expression
embryonic digit morphogenesis
epidermal cell differentiation
eyelid development in camera-type eye
fungiform papilla formation
gene expression
hair follicle placode formation
histone deacetylation
histone H3 deacetylation
histone H4 deacetylation
mitotic cell cycle
negative regulation by host of viral transcription
negative regulation of androgen receptor signaling pathway
negative regulation of apoptotic process
negative regulation of canonical Wnt signaling pathway
negative regulation of cell cycle
negative regulation of gene expression
negative regulation of gene expression, epigenetic
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
neurotrophin TRK receptor signaling pathway
Notch signaling pathway
odontogenesis of dentin-containing tooth
positive regulation of cell proliferation
positive regulation of receptor biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
protein deacetylation
regulation of gene expression, epigenetic
transcription initiation from RNA polymerase II promoter
transcription, DNA-templated
transforming growth factor beta receptor signaling pathway
viral process
Gene Ontology Biological Process:
ATP-dependent chromatin remodeling
blood coagulation
chromatin modification
chromatin organization
chromatin remodeling
circadian regulation of gene expression
embryonic digit morphogenesis
epidermal cell differentiation
eyelid development in camera-type eye
fungiform papilla formation
gene expression
hair follicle placode formation
histone deacetylation
histone H3 deacetylation
histone H4 deacetylation
mitotic cell cycle
negative regulation by host of viral transcription
negative regulation of androgen receptor signaling pathway
negative regulation of apoptotic process
negative regulation of canonical Wnt signaling pathway
negative regulation of cell cycle
negative regulation of gene expression
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
neurotrophin TRK receptor signaling pathway
Notch signaling pathway
odontogenesis of dentin-containing tooth
positive regulation of cell proliferation
positive regulation of receptor biosynthetic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
protein deacetylation
regulation of gene expression, epigenetic
transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
viral process
Gene Ontology Molecular Function:
activating transcription factor binding
core promoter binding
deacetylase activity
enzyme binding
histone deacetylase activity
histone deacetylase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
NF-kappaB binding
protein deacetylase activity
protein N-terminus binding
repressing transcription factor binding
RNA polymerase II repressing transcription factor binding
RNA polymerase II transcription corepressor activity
RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcription regulatory region DNA binding
transcription regulatory region sequence-specific DNA binding
Gene Ontology Cellular Component:
chromatin
cytoplasm
cytosol
histone deacetylase complex
nuclear chromatin
nucleoplasm
nucleus
NuRD complex
protein complex
Sin3 complex
Keywords:
3D-structure
Acetylation
Biological rhythms
Chromatin regulator
Complete proteome
Host-virus interaction
Hydrolase
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation
Interacts With:
Q9UKG1; Q14865; Q9C0K0; P29128; Q9HCU9; Q6PH81; Q14839; P68400; Q9UER7; Q92841-4; P17844; Q7L2E3; Q9UJW3; Q66K89; Q96KQ7; Q8N140; Q9NP50; Q99684; P51610; Q92769; P62805; Q9Y4K0; P43355; Q9UIS9; Q8N108; Q13330; Q9Y618; P19838; P06748; Q9Y5X4; Q9NQX1; Q96N64; P06400; Q09028; Q16576; Q04206; O00422; O95863; O43463; P04637

Publication

PubMed ID:
8602529 8646880 15489334 10487760 10898795 10846170 11006275 10669754 10655483 11602581 11331609 11102443 11427533 11533236 12032081 11960997 14633989 12670868 12493763 12837748 12482978 12724404 12730668 15451426 15454082 15273251 15199155 15361834 10904264 15927959 16166625 16569215 17081983 16478997 17000776 16820529 17963697 17487921 17548428 17373667 17704056 17872950 17341466 17369852 17996965 18093978 18691976 19061646 18438403 19081374 18669648 18318008 19413330 19049980 19343227 19182791 19690332 19608861 21030595 20081843 20068231 21269460 21549307 21829689 21406692 24275569 25218447 25772364 25755297 25653165