Names & Taxonomy
- Uniprot ID:
- Q13509
- Entry Name:
- TBB3_HUMAN
- Status:
- reviewed
- Protein Names:
- Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III)
- Gene Names:
- TUBB3 TUBB4
- Gene Names Primary:
- TUBB3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 450
- Sequence:
- MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYVPRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEMYEDDEEESEAQGPK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton.
Function
- Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.
- Cross Reference Drug Bank:
- DB04845
- Gene Ontology Go:
- axon
cell periphery
cytoplasm
dendrite
extracellular exosome
microtubule
neuronal cell body
nucleus
GTP binding
GTPase activity
peptide binding
structural constituent of cytoskeleton
'de novo' posttranslational protein folding
axon guidance
cellular protein metabolic process
microtubule-based process
mitotic nuclear division
protein folding - Gene Ontology Biological Process:
- 'de novo' posttranslational protein folding
axon guidance
cellular protein metabolic process
microtubule-based process
mitotic nuclear division
protein folding - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
peptide binding
structural constituent of cytoskeleton - Gene Ontology Cellular Component:
- axon
cell periphery
cytoplasm
dendrite
extracellular exosome
microtubule
neuronal cell body
nucleus - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
GTP-binding
Isopeptide bond
Microtubule
Nucleotide-binding
Phosphoprotein
Reference proteome - Interacts With:
- P54274; P68363