Names & Taxonomy
- Uniprot ID:
- Q13363
- Entry Name:
- CTBP1_HUMAN
- Status:
- reviewed
- Protein Names:
- C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)
- Gene Names:
- CTBP1 CTBP
- Gene Names Primary:
- CTBP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 440
- Sequence:
- MGSSHLLNKGLPLGVRPPIMNGPLHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAATHWASMDPAVVHPELNGAAYRYPPGVVGVAPTGIPAAVEGIVPSAMSLSHGLPPVAHPPHAPSPGQTVKPEADRDHASDQL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
- Cofactor:
- COFACTOR: Name=NAD(+); Xref=ChEBI:CHEBI:57540;
- Active Site:
- ACT_SITE 266 266
- Gene Ontology Go:
- cytoplasm
nucleoplasm
nucleus
transcription factor complex
transcriptional repressor complex
NAD binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
protein C-terminus binding
protein domain specific binding
protein homodimerization activity
repressing transcription factor binding
RNA polymerase II transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
transcription factor binding
negative regulation of cell proliferation
negative regulation of histone acetylation
negative regulation of histone H4 acetylation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter by histone modification
negative regulation of transcription, DNA-templated
positive regulation of histone deacetylation
protein phosphorylation
regulation of cell cycle
transcription, DNA-templated
viral genome replication
white fat cell differentiation - Gene Ontology Biological Process:
- negative regulation of cell proliferation
negative regulation of histone acetylation
negative regulation of histone H4 acetylation
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter by histone modification
positive regulation of histone deacetylation
protein phosphorylation
regulation of cell cycle
transcription, DNA-templated
viral genome replication
white fat cell differentiation - Gene Ontology Molecular Function:
- NAD binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
protein C-terminus binding
protein domain specific binding
protein homodimerization activity
repressing transcription factor binding
RNA polymerase II transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
transcription factor binding - Gene Ontology Cellular Component:
- cytoplasm
nucleoplasm
nucleus
transcriptional repressor complex
transcription factor complex - Keywords:
- 3D-structure
ADP-ribosylation
Alternative splicing
Complete proteome
Cytoplasm
Differentiation
Direct protein sequencing
Host-virus interaction
Isopeptide bond
NAD
Nucleus
Oxidoreductase
Phosphoprotein
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation - Interacts With:
- Q9H6U6; Q76N32; Q49AN0; P56545; Q8IY44; I6L9A0; O15409; Q9BXL5; Q14526; P09067; Q13422; Q9Y4X4; O43474; P45984; O94818-2; Q96MY1; Q9NQ66; Q13131; Q9NYB0; Q15583; Q96EK4; A1L0U7; A2APF7; Q8N895