Names & Taxonomy

Uniprot ID:
Q13363
Entry Name:
CTBP1_HUMAN
Status:
reviewed
Protein Names:
C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)
Gene Names:
CTBP1 CTBP
Gene Names Primary:
CTBP1
Organism:
Homo sapiens (Human)

Structure

Length:
440
Sequence:
MGSSHLLNKGLPLGVRPPIMNGPLHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAATHWASMDPAVVHPELNGAAYRYPPGVVGVAPTGIPAAVEGIVPSAMSLSHGLPPVAHPPHAPSPGQTVKPEADRDHASDQL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
Cofactor:
COFACTOR: Name=NAD(+); Xref=ChEBI:CHEBI:57540;
Active Site:
ACT_SITE 266 266
Gene Ontology Go:
cytoplasm
nucleoplasm
nucleus
transcription factor complex
transcriptional repressor complex
NAD binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
protein C-terminus binding
protein domain specific binding
protein homodimerization activity
repressing transcription factor binding
RNA polymerase II transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
transcription factor binding
negative regulation of cell proliferation
negative regulation of histone acetylation
negative regulation of histone H4 acetylation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter by histone modification
negative regulation of transcription, DNA-templated
positive regulation of histone deacetylation
protein phosphorylation
regulation of cell cycle
transcription, DNA-templated
viral genome replication
white fat cell differentiation
Gene Ontology Biological Process:
negative regulation of cell proliferation
negative regulation of histone acetylation
negative regulation of histone H4 acetylation
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter by histone modification
positive regulation of histone deacetylation
protein phosphorylation
regulation of cell cycle
transcription, DNA-templated
viral genome replication
white fat cell differentiation
Gene Ontology Molecular Function:
NAD binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
protein C-terminus binding
protein domain specific binding
protein homodimerization activity
repressing transcription factor binding
RNA polymerase II transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
transcription factor binding
Gene Ontology Cellular Component:
cytoplasm
nucleoplasm
nucleus
transcriptional repressor complex
transcription factor complex
Keywords:
3D-structure
ADP-ribosylation
Alternative splicing
Complete proteome
Cytoplasm
Differentiation
Direct protein sequencing
Host-virus interaction
Isopeptide bond
NAD
Nucleus
Oxidoreductase
Phosphoprotein
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation
Interacts With:
Q9H6U6; Q76N32; Q49AN0; P56545; Q8IY44; I6L9A0; O15409; Q9BXL5; Q14526; P09067; Q13422; Q9Y4X4; O43474; P45984; O94818-2; Q96MY1; Q9NQ66; Q13131; Q9NYB0; Q15583; Q96EK4; A1L0U7; A2APF7; Q8N895

Publication

PubMed ID:
7479821 9858600 15815621 15489334 8440238 11568182 11462050 11509661 12372828 12679040 14567915 15542832 15060175 16061479 15897867 16609867 16702210 17085477 17525332 18212045 19103759 21269460 23747199 24275569 25728771 12419229