Names & Taxonomy

Uniprot ID:
Q13362
Entry Name:
2A5G_HUMAN
Status:
reviewed
Protein Names:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29)
Gene Names:
PPP2R5C KIAA0044
Gene Names Primary:
PPP2R5C
Organism:
Homo sapiens (Human)

Structure

Length:
524
Sequence:
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAHQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus. Chromosome, centromere.

Function

Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
Gene Ontology Go:
chromosome, centromeric region
nucleus
protein phosphatase type 2A complex
protein phosphatase type 2A regulator activity
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of cell proliferation
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of protein phosphatase type 2A activity
signal transduction
Gene Ontology Biological Process:
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of cell proliferation
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of protein phosphatase type 2A activity
signal transduction
Gene Ontology Molecular Function:
protein phosphatase type 2A regulator activity
Gene Ontology Cellular Component:
chromosome, centromeric region
nucleus
protein phosphatase type 2A complex
Keywords:
3D-structure
Acetylation
Alternative splicing
Centromere
Chromosome
Complete proteome
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Interacts With:
O96017; P46695; Q00987; P67775; P30153; P30154; P04637

Publication

PubMed ID:
8617797 8694763 14702039 19054851 12508121 7584044 7592815 8703017 10508479 16580887 16456541 16541025 17245430 17967874 22814378 17174897 17086192 19716788 18618707