Names & Taxonomy
- Uniprot ID:
- Q13362
- Entry Name:
- 2A5G_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29)
- Gene Names:
- PPP2R5C KIAA0044
- Gene Names Primary:
- PPP2R5C
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 524
- Sequence:
- MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAHQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Chromosome, centromere.
Function
- Function:
- The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
- Gene Ontology Go:
- chromosome, centromeric region
nucleus
protein phosphatase type 2A complex
protein phosphatase type 2A regulator activity
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of cell proliferation
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of protein phosphatase type 2A activity
signal transduction - Gene Ontology Biological Process:
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of cell proliferation
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of protein phosphatase type 2A activity
signal transduction - Gene Ontology Molecular Function:
- protein phosphatase type 2A regulator activity
- Gene Ontology Cellular Component:
- chromosome, centromeric region
nucleus
protein phosphatase type 2A complex - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Centromere
Chromosome
Complete proteome
Nucleus
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- O96017; P46695; Q00987; P67775; P30153; P30154; P04637