Names & Taxonomy
- Uniprot ID:
- Q13285
- Entry Name:
- STF1_HUMAN
- Status:
- reviewed
- Protein Names:
- Steroidogenic factor 1 (SF-1) (STF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP)
- Gene Names:
- NR5A1 AD4BP FTZF1 SF1
- Gene Names Primary:
- NR5A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 461
- Sequence:
- MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
- Gene Ontology Go:
- nucleoplasm
nucleus
RNA polymerase II transcription factor complex
chromatin binding
DNA binding
enzyme binding
phospholipid binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid hormone receptor activity
transcription coactivator activity
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription regulatory region sequence-specific DNA binding
zinc ion binding
adrenal gland development
cell differentiation
cell-cell signaling
gene expression
hormone metabolic process
hormone-mediated signaling pathway
intracellular receptor signaling pathway
luteinization
maintenance of protein location in nucleus
male gonad development
multicellular organism aging
negative regulation of female gonad development
positive regulation of male gonad development
positive regulation of transcription from RNA polymerase II promoter
primary sex determination
regulation of steroid biosynthetic process
tissue development
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- adrenal gland development
cell-cell signaling
cell differentiation
gene expression
hormone-mediated signaling pathway
hormone metabolic process
intracellular receptor signaling pathway
luteinization
maintenance of protein location in nucleus
male gonad development
multicellular organism aging
negative regulation of female gonad development
positive regulation of male gonad development
positive regulation of transcription from RNA polymerase II promoter
primary sex determination
regulation of steroid biosynthetic process
tissue development
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- chromatin binding
DNA binding
enzyme binding
phospholipid binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid hormone receptor activity
transcription coactivator activity
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription regulatory region sequence-specific DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- nucleoplasm
nucleus
RNA polymerase II transcription factor complex - Keywords:
- 3D-structure
Acetylation
Activator
Complete proteome
DNA-binding
Disease mutation
Isopeptide bond
Lipid-binding
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Premature ovarian failure
Receptor
Reference proteome
Transcription
Transcription regulation
Ubl conjugation
Zinc
Zinc-finger - Interacts With:
- O43639; P51843